Phonopheresis Versus Topical Salvadora Persica in Healing of Full-Thickness Wound: An experimental Study

Objective: To compare and investigate the effect of phonopheresis and topical salvadora persica on wound healing in rats. Design: Randomized, controlled trial. Settings: University animal laboratory. Animals: 45 adult albino male rats allocated to A, B and C groups. Interventions: After anesthesia, a wound area of 5cm2 was made on the upper dorsum of all rats. Group A was treated with phonopheresis, with frequency of 1MHz, intensity of 0.5W/cm2 and duty cycle of 40%, group B received sham phonopheresis while group C received sham ultrasonic, and treatment duration for all was six minutes/session/8 sessions. Wounds were captured by digital camera and were measured using trace method. Outcome measures: healing represents decreased in wound surface area. Results: there was a significant sequential reduction in wound surface area throughout 1st, 3rd, 5th and 8th sessions in all three groups. There was significant difference between; mean of W.S.A in group (A) and mean of W.S.A in group (B) at3rd ,5th and 8th sessions as p value (.09), (0.029) and (0.004) respectively, also there was significant difference between; mean of W.S.A in group (A) and mean of W.S.A in group (C) at 3rd, 5th and 8th sessions as p value (0.003),(0.00001) and (0.00001) respectively, while there was significant difference between; mean of W.S.A in group(B) and mean of W.S.A in group (C) at 3rd, 5th and 8th sessions as p value (0.024), (0.00001) and (0.021) respectively. Conclusion: phonophersis and topical salvadora persica gel have satisfied effect on wound healing. In addition, better healing provided by phonopheresis