10Aug 2017

FROSTBITE WOUND HEALING ACTIVITY OF IBUPROFEN NANOEMULSION BASED GEL WITH THE FRACTIONAL DOSE FOR EXTRACTION OF MIMOSA PUDICA LEAVES.

  • Department of Pharmaceutics, Girijanadha Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India, 781017.
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The main aim of this study is to determine formulation, Development and Optimization of novel nanoemulsion formulation and treatment of frostbite injury with the fractional dose of Mimosa pudica leaves. Materials Ibuprofen as active ingredient was collected from the Merck Specialities private Ltd. Oleic acid and glycerol, and PEG 400, was collected from the Merck Specialities Private Ltd, Ethanol was collected from China, (Changshu Yangyuan Chemicals), Petroleum ether parches from the Merck Specialities private Ltd, Extract Raw material Mimosa pudica was collected from the Azara, Guwahati local area and air dried and powered the leaves. Nanoemulsion prepared by high pressure homogenization method. Characterization of Nanoemulsion was done to determine the thermodynamic Stability, Dynamic Light Scattering Spectrophotometer, Zeta Potential, Transmission Electron Microscopy (TEM), Drug Content, Viscosity Measurement and in-vitro drug released. It shows as good characteristic of nanoemulsion and can be predicted particle range from 200 to 252 nm. Zeta potential conductivity 0.0910 mV to 0.00363 mS/ Cm found for nanoemulsion formulation. Apart from these SEM and TEM was carried out which shows very small particle and well distribution. Irritation and antinflammatory done by direct applying the formulation topically and observed for 15 to 20 days.

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[Akkas Ali Ahmed and Suvakanta Dash. (2017); FROSTBITE WOUND HEALING ACTIVITY OF IBUPROFEN NANOEMULSION BASED GEL WITH THE FRACTIONAL DOSE FOR EXTRACTION OF MIMOSA PUDICA LEAVES. Int. J. of Adv. Res. 5 (Aug). 69-86] (ISSN 2320-5407). www.journalijar.com

Akkas Ali Ahmed
Department of Pharmaceutics, Girijanadha Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India, 781017

DOI:

Article DOI: 10.21474/IJAR01/5036      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5036

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