15Aug 2017

PROFILE OF HEPATO-RENAL DYSFUNCTION IN MALARIA.

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Introduction: Severe malaria infection is increasingly observed now a days in this region of Rohilkhand. Organ failure is caused by mechanism of inflammation as well as sequestration. In this study we have tried to explore the hepato-renal dysfunction in malaria. Material and Methods: Fifty adult malaria proved cases over the period of one and half year were included in this study. Malaria was detected with smear or rapid diagnostic test for malarial parasite or malaria antigen (LDH) spot test. They were subjected to detailed history, physical examination, course of the disease, hepatic and renal function test along with routine investigations. Result: 38% were of mixed infection, 28% P. vivax and 34% P. falciparum. Amongst organomegaly the spleen was enlarged in 44% of cases and hepatosplenomegaly in 24% of cases. Icterus was seen in 52% of cases with hyperbilirubinaemia (S.bilirubin>2.5mg) in 62% and raised transaminases more than two folds in 62% of cases. Patients with renal dysfunction presented with electrolyte abnormality (S.sodium<135meq/l in 30% cases, S.potassium>5.5 meq/l in 12% cases) abnormal urinary sediments in 54% cases with increased protein excretion (>500 mg/day) in 36% of cases. Blood urea was raised (> 80 mg %) in 28% and serum creatinine in 20% of cases (>2.6 mg%). Conclusion: Malarial infection i.e. P. vivax, P. falciparum and mixed infection is an important cause of hepato-renal dysfunction which usually lead to acute renal failure and/or hepato-renal failure. Fatality of P.vivax is equally important in comparision to P.falciparum and mixed infection.

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[Sumit sawhney. (2017); PROFILE OF HEPATO-RENAL DYSFUNCTION IN MALARIA. Int. J. of Adv. Res. 5 (Aug). 666-670] (ISSN 2320-5407). www.journalijar.com

Sumit Sawhney

DOI:

Article DOI: 10.21474/IJAR01/5104      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5104

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