Synthesis of Potent Antimicrobial Pyrrole Derivatives

Maher A. El-Hashash; Sherif M. Sherif; Azza A. E. Badawy; Huda R. M. Rashdan

30 May 2014 Vol. 2 (05)

Synthesis of Potent Antimicrobial Pyrrole Derivatives

Maher A. El-Hashash, Sherif M. Sherif, Azza A. E. Badawy, Huda R. M. Rashdan

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Abstract

Several new pyrrole derivatves were synthesized via the reaction of 2,5-dihydro-4,5-bis(4-methoxyphenyl)-2-Thioxo-1H-pyrrole-3-carbonitrile with ethyl chloroacetate, chloroacetone, ?-bromoacetophenone, ?-bromo-4-methylacetophenone, chloroacetonitrile or iodomethane to give the corresponding s-alkylated derivatives. In addition, the antimicrobial activity of some selected derivatives was studied.

How to Cite This Article

Maher A. El-Hashash, Sherif M. Sherif , Azza A. E. Badawy, Huda R. M. Rashdan (2014); Synthesis of Potent Antimicrobial Pyrrole Derivatives, International Journal of Advanced Research (IJAR), 2 (05), 0, ISSN 2320-5407.

Corresponding Author

Huda Refaat Mahmoud Rashdan

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