10Aug 2017

PATTERNS OF FAILURE AND FACTORS AFFECTING IT IN CARCINOMA CERVIX STAGE (IIB - IVA) TREATED WITH CHEMORADIOTHERAPY OR RADIOTHERAPY ALONE.

  • PG Residents, Department of Radiotherapy, Medical College Hospital, Kolkata.
  • Assistant Professor, Department of Radiotherapy, Medical college Hospital, Kolkata.
  • Professor, Department of Radiotherapy, Medical College Hospital, Kolkata.
  • Professor & Head, Department of Radiotherapy, Medical College Hospital, Kolkata.
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Introduction: Several factors i.e. age, anthropometric parameters, socio-economic profile, Histopathology, lymph node status not considered in staging & treatment outcome have definitely a conclusive role in treatment response & recurrence. Also there are acute & late toxicities occur at different stages of treatment i.e cervical os stenosis, vaginal atrophy, bowel & bladder toxicities. Recently different studies are being conducted evaluating overall survival (OS), disease free survival, progression of disease, recurrence, patterns of recurrence (local or distant) & factors affecting it. Multiple patient related & treatment related factors have impact on disease outcome. So it is very important to assess the patterns of failure & the factors affecting it in a cohort of patients treated in a single institution. In this retrospective study, we have tried to evaluate recurrence & its patterns, time to recurrence & factors affecting it. Material & Methods: A retrospective single institutional study including patients of CA cervix from stage IIB ? IV A, from December 2014 ? May 2016. Various parameters were studied with their relation with 3yr DFS & 3yr overall survival. Statistical Analysis was done by SPSS V.23, using standard statistical tests. Results: Factors i.e age at presentation, age at marriage, age of 1st child birth, parity, tobacco addiction, other co-morbid medical conditions, Pre-treatment Hb%<11gm/dl, treatment type ( RT alone), overall treatment time(>56D), Tumour volume (>4cm), Both parametrium involvement, Delay in diagnosis, Gap between EBRT & ICRT, Gross residual tumour after EBRT have significant association with recurrence, recurrence pattern & 3 year survival. Among them age at presentation, L.N involvement, overall treatment time are found as significant prognostic factor in multivariate analysis. Conclusions: The findings of this study are not conclusive as a result of the small sample size & single institutional, Retrospective study. Further multicenter, controlled, randomized phase III trials will be needed to prove the factors affecting the treatment failure.

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[Avik Maji, Abhishek Basu, Bidyut Mandal and Swapan Kr Sikdar and Shyamal Sarkar. (2017); PATTERNS OF FAILURE AND FACTORS AFFECTING IT IN CARCINOMA CERVIX STAGE (IIB - IVA) TREATED WITH CHEMORADIOTHERAPY OR RADIOTHERAPY ALONE. Int. J. of Adv. Res. 5 (Aug). 444-451] (ISSN 2320-5407). www.journalijar.com

Dr.Abhishek Basu
DEPARTMENT OF RADIOTHERAPY, MEDICAL COLLEGE HOSPITAL,KOLKATA

DOI:

Article DOI: 10.21474/IJAR01/5077      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5077

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