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Epigenetic is referred to as the study of changes which are heritable in gene expression that happen without a DNA sequence change. Effective research has shown that epigenetic mechanisms provide an added layer of transcriptional control which helps regulate the expression of genes. In the normal growth and development of cells, the above mechanisms are said to be very critical components. The abnormalities of epigenetic are said to be causive factors in genetic disorders, cancer and pediatric syndrome. In this paper, we tend to look at the various diseases associated or caused by epigenetic and how they affect the body. The paper will also examine how epigenetic therapy helps combat these diseases. Epigenetic abnormalities are also said to be a contributing factor to aging and autoimmune diseases. This review will try to examine the major principles of the mechanisms of epigenetic and their different ways of contributing towards the human health together with the consequences of clinical errors in epigenetic. The review will also look at the pathways of epigenetic in the upcoming approaches towards the treatment and also the diagnosis in the clinical spectrum. Diseases that associate with epigenetic come with serious body effects especially those connected with cancer and obesity. This review will give a clear look at the body impact these diseases expose to human beings and how they affect them psychologically and emotionally. The paper will also analyze the research that is being carried out by the medical researchers in order to provide epigenetic treatments to those patients who are affected by epigenetic associated diseases.