29Aug 2017

AWARENESS AND KNOWLEDGE OF TITANIUM ALLERGY AMONG DENTAL STUDENTS IN VARIOUS INSTITUTIONS - A SURVEY.

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Aim: To evaluate titanium allergy in prosthodontics and its effects on human health Objective: To study the use of titanium in dental procedures and its action in allergic reactions Background: In dentistry, titanium is considered as a material of choice for various dental procedures such as dental implants, partial dentures and fabrication of crowns. Titanium can form passive, stable oxide film as it has a high resistance to corrosion in physiological environment and excellent biocompatibility. Titanium may act as an allergen that induces clinically relevant hypersensitivity and other immune dysfunctions when exposed to sensitive patients. The use of titanium as biomedical devices may stimulate type I or type IV reactions in allergic patients that can be characterized by various conditions such as skin rashes and non-specific immune suppression Materials and Method: A questionnaire survey was conducted among 100 dental students from various institutions. All participants were provided with a list of 10 questions related to titanium allergy. Data was collected and statistic analysis was done.


  1. Smith D, Lugowski S, Mchugh A, Deporter D, Watson P, Chipman M. Systemic metal ion levels in dental implant patients.?Int J Oral Maxillofac Implants.?1996;12:828?34.?[PubMed]
  2. Sykaras N, Iacopino A, Marker V, Triplett R, Woody R. Implant materials, designs, and surface topographies: Their effect on osseointegration. A literature review.?Int J Oral Maxillofac Implants.?1999;15:675?90.?[PubMed]
  3. Frisken KW, Dandie GW, Lugowski S, Jordan G. A study of titanium release into body organs following the insertion of single threaded screw implants into the mandibles of sheep.?Aust Dent J.?2002;47:214?7.?[PubMed]
  4. Akagawa Y, Abe Y. Titanium: The ultimate solution or an evolutionary step??Int J Prosthodont.?2003;16(Suppl):28?9.[PubMed]
  5. Schramm M, Pitto RP. Clinical relevance of allergological tests in total hip joint replacement. In: Willmann G, Zweymuller K, editors.?Bioceramics in Hip joint replacement.?New York, USA: Thieme; 2000. pp. 101?6.
  6. Hallab N, Merritt K, Jacobs J. Metal sensitivity in patients with orthopaedic implants.?J Bone Joint Surg Am.?2001;83:428?36.[PubMed]Sicilia, A., Cuesta, S., Coma, G., Arregui, I., Guisasola, C., Ruiz, E. and Maestro, A., 2008. Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients.?Clinical oral implants research,?19(8), pp.823-835.
  7. Evrard, L., 2011.?Titanium: a new allergen. INTECH Open Access Publisher.
  8. Hallab M, Mikecz K, Vermes C, Skipor A, Jacobs J. Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation.?J Biomed Mater Res.?2001;56:427 36.[PubMed]
  9. Forte G, Petrucci F, Bocca B. Metal allergens of growing significance: Epidemiology, immunotoxicology, strategies for testing and prevention.?Inflamm Allergy.?2008;7:1?18.?[PubMed]
  10. Goutam, M., Giriyapura, C., Mishra, S.K. and Gupta, S., 2014. Titanium allergy: A literature review.?Indian journal of dermatology,?59(6), p.630.
  11. Wood M M,?Warshaw E M.?Hypersensitivity reactions to titanium: diagnosis and management.?Dermatitis2015:?26:?7?25.
  12. Vijayaraghavan V,?Sabane A V,?Tejas K.?Hypersensitivity to titanium: a less explored area of research.?J Indian Prosthodont Soc2012:?12:?201?207.
  13. [14] Peira E,?Turci F,?Corazzari I?et al.?The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO in ex vivo pig skin model under indoor light.?Int J Pharm2014:?467:?90?99.
  14. Wiesenthal A,?Hunter L,?Wang S?et al.?Nanoparticles: small and mighty.?Int J Dermatol2011:?50:?247?254.
  15. Keegan G M,?Learmonth I D,?Case C P.?Orthopaedic metals and their potential toxicity in the arthroplasty patient: a review of current knowledge and future strategies.?J Bone Joint Surg Br2007:?89:?567?573.
  16. Bilhan H,?Bural C,?Geckili O.?Titanium hypersensitivity. A hidden threat for dental implant patients??N Y State Dent J2013:?79:?38?43.
  17. Palanuwech, M.?The Fatigue Resistance of Pure Titanium(grade II), Titanium Alloy (Ti6Al7Nb) and Cobalt-Chromium Cast Clasps. University Centre of Dentistry, Oral Medicine and Maxillofacial Surgery,?T?bingen,?2003
  18. Wang W,?Poh CK.?Titanium Alloys?Advances in Properties Control. In:?Titanium Alloys in Orthopaedics,?Sieniawski J?(ed.): InTech,?2013. ISBN: 978-953-51-1110-8,
  19. Robichaud C O,?Uyar A E,?Darby M R?et al.?Estimates of upper bounds and trends in nano-TiO2production as a basis for exposure assessment.?Environ Sci Technol?2009:?43:?4227?4233.
  20. Peters, M.S., Schroeter, A.L., Hale, H.M. and Broadbent, J.C., 1984. Pacemaker contact sensitivity.?Contact dermatitis,?11(4), pp.214-218.
  21. Yamauchi, R., Morita, A. and Tsuji, T., 2000. Pacemaker dermatitis from titanium.?Contact dermatitis,?42(1), pp.52-53.
  22. Egusa, H., Ko, N., Shimazu, T. and Yatani, H., 2008. Suspected association of an allergic reaction with titanium dental implants: a clinical report.?The Journal of prosthetic dentistry,?100(5), pp.344-347.
  23. Muller, K. and Valentine-Thon, E., 2006. Hypersensitivity to titanium: clinical and laboratory evidence.?Neuroendocrinology Letters,?27(1), pp.31-35.
  24. Stejskal, V.D.M., Cederbrant, K., Lindvall, A. and Forsbeck, M., 1994. MELISA?an in vitro tool for the study of metal allergy.?Toxicology in vitro,?8(5), pp.991-1000.
  25. Ko, N., Mine, A., Egusa, H., Shimazu, T., Ko, R., Nakano, T. and Yatani, H., 2014. Allergic Reaction to Titanium‐Made Fixed Dental Restorations: A Clinical Report.?Journal of Prosthodontics,?23(6), pp.501-503.
  26. Hosoki, M., Nishigawa, K., Miyamoto, Y., Ohe, G. and Matsuka, Y., 2016. Allergic contact dermatitis caused by titanium screws and dental implants.?Journal of prosthodontic research,?60(3), pp.213-219.
  27. Elias C, Lima J, Valiev R, Meyers M. Biomedical applications of titanium and its alloys.?J Miner Met Mater Soc.?2008;60:46?9.
  28. Parr GR, Gardner LK, Toth RW. Titanium: The mystery metal of implant dentistry. Dental materials aspects.?J Prosthet Dent.?1985;54:410?4.?[PubMed]
  29. Abdallah HI, Balsara RK, O?Riordan AC. Pacemaker contact sensitivity: Clinical recognition and management.?Ann Thorac Surg.?1994;57:1017?8.?[PubMed]
  30. Torgersen S, Gjerdet N, Erichsen E, Bang G. Metal particles and tissue changes adjacent to miniplates: A retrieval study.?Acta Odontol.?1995;53:65?71.?[PubMed]
  31. Haug RH. Retention of asymptomatic bone plates used for orthognathic surgery and facial fractures.?J Oral Maxillofac Surg.?1996;54:611?7.?[PubMed]
  32. Matthew IR, Frame JW. Ultrastructural analysis of metal particles released from stainless steel and titanium miniplate components in an animal model.?J Oral Maxillofac Surg.?1998;56:45?50.?[PubMed]
  33. Mitchell DL, Synnott SA, Van Dercreek JA. Tissue reaction involving an intraoral skin graft and CP titanium abutments: A clinical report.?Int J Oral Maxillofac Implants.?1990;5:79?84.?[PubMed]
  34. Kadambari Sriram et al. Awareness of allergic reactions to dental drugs
  35. and materials among patients, dentists and dental personnel - a cross sectional study /J. Pharm. Sci. & Res. Vol. 8(9), 2016, 1050-1057 1056.

[Nur liyana hannah binti izham akmal and dr. Sangeetha kiruba. (2017); AWARENESS AND KNOWLEDGE OF TITANIUM ALLERGY AMONG DENTAL STUDENTS IN VARIOUS INSTITUTIONS - A SURVEY. Int. J. of Adv. Res. 5 (Aug). 1979-1990] (ISSN 2320-5407). www.journalijar.com


NUR LIYANA HANNAH BINTI IZHAM AKMAL, DR. SANGEETHA KIRUBA


DOI:


Article DOI: 10.21474/IJAR01/5263      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5263