15Aug 2017

OSTEOPROTEGRIN AS A PREDICTOR OF CORONARY ARTERY DISEASE IN TYPE II DIABETES MELLITUS

  • Department of Internal Medicine - Faculty of Medicine (Girls) -Al-Azhar University.
  • Department of cardiology - Faculty of Medicine (Girls) -Al-Azhar University.
  • Department of Clinical and Chemical Pathology-National Research Centre (NRC).
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Background: Coronary artery disease (CAD)is the most important factor related to increased morbidity and mortality in type2 diabetic patients, particularly in patients with albuminuria.Osteoprotegrin (OPG) is glycoprotein that is present in the arterial wall and increases its serum level reflects the increased OPG content in atherosclerotic arterial tissue. OPG is a mediator of vascular calcification. Objective: The aim of this study is to investigate the role of OPG as a potential risk marker for identification of early coronary artery disease in asymptomatic diabetic patient. Materials and methods: This cross section study was conducted on 60 diabetic patients with type 2 DM and were classified into: group (1) 30 diabetic patients without micro-albuminuria and group (2) 30 diabetic patients with micro-albuminuria compared to 30 healthy controls of the same age and sex. Routine laboratory investigations, fasting insulin level from which HOMA-IR was calculated, albumin to creatinine ratio, pro brain natriuretic peptide, serum OPG were measured in both patients and healthy controls. Thallium scan for group2were performed to detect ischemic heart disease Results: There was significant increase of serum OPG level in diabetic patients when compared to control group, and significant increase of serum OPG level in group2 when compared to group1. Conclusion: The study concluded that serum level of OPG was higher in type2 diabetic patients compared to control group and it increased in diabetic patients with micro vascular complications. This marker could be used for the early diagnosis of subclinical atherosclerosis.

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[Huda M. El Sayed, Maha A.Hassan, Emad A. Said, Mona N.Ali, Nagwa A. Mohamed and Hanaa M. Eid. (2017); OSTEOPROTEGRIN AS A PREDICTOR OF CORONARY ARTERY DISEASE IN TYPE II DIABETES MELLITUS Int. J. of Adv. Res. 5 (Aug). 753-763] (ISSN 2320-5407). www.journalijar.com

Maha Abdallah Hassan

DOI:

Article DOI: 10.21474/IJAR01/5116      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5116

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