31Aug 2017

ANTIBACTERIAL SCREENING OF ALKALOID EXTRACTS FROM WALTHERIAINDICALEAVES.

  • Department of Biotechnology, ModibboAdama University of Technology, Yola, Adamawa State,Nigeria.
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Leaves of Waltheriaindica is used for the treatment of various illness via traditional medicine practices. Studies have described a range of bioactive compounds extracted from different plant parts which include alkaloids. The effect of these alkaloids alone against gram positive, gram negative bacteria and pathogenic fungi as well as the nutritional value of the leaves was evaluated. Extracted alkaloid base displayed resistance to Candida krusei (25?0.10mm), Candida tropicalis (23?0.25mm), Klebsiella pneumonia (24?0.45mm), Staphylococcus aureus (24?0.75mm) and Streptococcus pneumonia (28?0.90mm) using Ciprofloxacin (0.1 mg/ml) and Fluconazole (0.3mg/ml) as controls. Minimum Inhibitory Concentrationvalues in the range of 0.25 ? 0.75 mg/ml were observed. Minimum Bacterial Concentrations of 1.25mg/ml, 1.0mg/ml and 0.75mg/ml were observed against K. pneumonia, S. aureus and S. pneumonia respectively. TheMinimum Fungal Concentrations of 0.75mg/ml and 1.25mg/ml were observed against C. krusei and C. tropicalis respectively. Proximate analysis revealed that Waltheriaindica leaves contain crudeprotein(18.74%), crude fiber (15.06%), moisture (8.23%), total ash (7.37%), total carbohydrate(55.95%). The results obtained suggested that the alkaloid base of Waltheriaindica may proffer alternative lead compounds towards the development of new plant-based antibiotic and anti-fungal agents.

  1. , and Hoper W., (2010). Antibacterial activity of Artemisia nilagiricaleaf extract against clinical and phytopathogenic bacteria. BMC Complementary and Alternative Medicine, 10: 6-11.
  2. Akoachere J. F. T. K., Suylika Y., Njom H. A., and Esemu N. K., (2012). Etiologic profile and antimicrobial susceptibility of community acquired urinary tract infection in two Cameroonian towns. BMC Research Notes, 5:
  3. Ara N., Nur M. H., Amran M. S., Wahid M. I. I., and Ahmed M., (2009).In vitro antimicrobial and cytotoxic activities of leaves and flowers extracts from Pakistan Journal of Biological Sciences, 12: 87?90.
  4. Balunas M. J., and Kinghorn A. D., (2005). Drug discovery from medicinal plants. Life Science Journal, 78: 431-441.
  5. Beltrame A., Angheben A., and Bisoffi Z., (2007). Imported chikungunya infection, Italy. Emerging Infectious Diseases,13: 1264?1266.
  6. Chen L., and Fadamiro H. Y., (2009). Re-investigation of venom chemistry of Solenopsisfire ants. I. Identification of novel alkaloids in Richteri. Toxicology, 53: 469-478.
  7. Chitemerere T. A., and Mukanganyama S., (2011).In-vitro antibacterial activity of selected medicinal plants from Zimbabwe. African Journal of Plant Science and Biotechnology, 5: 1?7.
  8. Duraipandiyan V., Ayyanar M., and Ignacimuthu S., (2006). Antimicrobial activity of some ethnomedical plants used by Paliyar Tribe from Tamil Nadu, India. BMC Complementary and Alternative Medicine, 6: 635-641.
  9. Gautam R., Saklani A., and Jachak S. M., (2007). Indian medicinal plants as a source of anti-mycobacterial agents. Journal of Ethnopharmacology, 110: 200-234.
  10. Gbadamosi I. T., Moody J. O., Yekini A. O., (2012). Nutritional Composition of Ten Ethnobotanicals Used for the Treatment of Anaemia in Southwest Nigeria. European Journal of Medicinal Plants, 2: 140-150.
  11. Kennedy D. O., and Wightman E. L., (2011). Herbal Extracts and Phytochemicals: Plant Secondary Metabolites and the Enhancement of Human Brain Function. Advances in Nutrition,2: 32?50.
  12. Mabhiza D., Chitemerere T., and Mukanganyama S., (2016). Antibacterial Properties of Alkaloid Extracts from Callistemon citrinusand Vernoniaadoensisagainst Staphylococcus aureus and Pseudomonas aeruginosa. International Journal of Medicinal Chemistry, 1-7.
  13. Mcginn D., and Ahlawa M., (2003). How contagious are common respiratory pathogens. New England Journal of Medicine, 348: 1256?1266.
  14. Mishra A. K., Mishra A., Kehri H. K., Sharma B., and Pandey A. K., (2009). Inhibitory activity of Indian spice plant Cinnamomumzeylanicum extracts against Alternariasolani and Curvularialunata, the pathogenic dematiaceous moulds. Annals in Clinical Microbiology and Antimicrobials,8:
  15. Mohammed Z., Shok M., iiyas N., Musa K. Y., Yaro A. H., (2007). Analgesic activity of Waltheriaindica.European Journal of Scientific Research, 16: 1-6.
  16. Nichol K.L., D?Heilly S., and Ehlinger E., (2005). Colds and influenza ? like illness in University students. Impact on Health, Academic and Work Performance and Health Care Use. Clinica and Infectious Disease Journal, 40: 1263?1270.
  17. Ngwu N. W., Effa E. B., Ftepti B. J., Gali A. I., Useh M. U., and Samuel C. J., (2016). Biochemical Studies of Ocimum sanctum and olaxsubscorpioidealeaf Extracts. British Journal of Pharmaceutical Research, 12:1-9.
  18. Okwute S. K., Olajide O. O., Etuk-Udo G., and Orishadipe A. T., (2016).Phytochemical Screening, In-vitro antimicrobialactivity and Antioxidant Characteristics oftetrapleuratetrapteraEuropean Journal of Medicinal Plants, 17:1-10.
  19. Olajuyigbe O. O., Babalola A. E., Afolayan A. J., (2011). Antibacterial and phytochemical screening of crude ethanolic extract of waltheriaindica African Journal of Microbiology Research, 5: 3760-3764.
  20. Ramanathan R., Baby R., Bhuvaneswarri R., and Dhandapani R., (2013). Antimicrobial activities of Canthiumparviflorum Andpergulariadaemia(Forsk) Chiov. International Journal of Comprehensive Pharmacy, 4: 205-209.
  21. Rao G., Zhang S., Wanga H., Li Z., Gao S., and Xu G., (2009). Antifungal alkaloids from the fresh rattan stem of fibraurearecisa Journal of Ethnopharmacology,123: 1-5.
  22. Reymond P., Weber H., Damond M., and Farmer E. E., (2000). Differential gene expression in response to mechanical wounding and insect feeding in Plant Cell,12: 707?719.
  23. Tamta M., Kumar A., Shukla N., and Negi D., (2012). Effects of crude extracts of premnabarbatawall and clerodendrumviscosum (Verbenaceae) on different pathogenic bacteria. Asian Journal of Traditional Medicine, 7: 1-7.
  24. Tanaka J. C. A., da Silva C. C., de Oliveira A. J. B., Nakamura C. V., and Dias-Filho B. P., (2006). Antibacterial activity of indole alkaloids from Brazilian Journal of Medical Biology Research, 39: 387-391.
  25. Trautmann M., Halder S., Hoegel J., Royer H., and Haller M., (2008). Point-of-use filtration reduces endemic Pseudomonas aeruginosa infections on a surgical intensive care unit. American Journal of Infection Control, 36: 421-429.
  26. Usman H., Abdulrahman F. K., and Ladan A. A., (2007). Phytochemical and Antimicrobial Evaluation of L. (Zygophylaceae) Growing in Nigeria. Medwell Research Journal of Bioscience, 2: 244-247.
  27. Uttu A. J., Sallau M. S., Hamisu I., Mubarak B. D., and Abdullahi Y. I., (2015). Phytochemical and antimicrobial screening of stem bark extracts from Glossonemaboveanum(Decne). Journal of Pharmacognosy and Phytochemistry,4: 86-88.
  28. Zailani A. H., Jada S. M., and Wurochekke U. A., (2011). Antimicrobial activity of Waltheriaindica. Journal of American Sciences, 6: 1591-1594.
  29. Zignol M., Hosseini M. S., Wright A., Lambregts C., Weezenbeek V., Nunn P., Watt C. J., Williams B. G., and Dye C., (2006). Global incidence of multidrug-resistant tuberculosis. Journal of Infectious Diseases, 194: 479?485.

[ Ftepti Benson Jelani. (2017); ANTIBACTERIAL SCREENING OF ALKALOID EXTRACTS FROM WALTHERIAINDICALEAVES. Int. J. of Adv. Res. 5 (Aug). 2012-2017] (ISSN 2320-5407). www.journalijar.com

Ftepti Benson Jelani
Department of Biotechnology, ModibboAdama University of Technology, Yola, Adamawa State,Nigeria.

DOI:

Article DOI: 10.21474/IJAR01/5267      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5267

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