31Aug 2017

PHYSICAL EXERCISE INDUCES IRISIN LEVELS ASSOCIATED WITH IMPROVED COGNITIVE FUNCTIONS AND GLUCOSE TOLERANCE IN OBESE AND NORMAL WEIGHT EGYPTIAN SUBJECTS: A 3-MONTH INTERVENTIONAL STUDY.

  • Department of Neurology, Faculty of Medicine, Zagazig University.
  • Department of Public Health and Community Medicine, Faculty of Medicine, Zagazig University.
  • Department of Physiology, Faculty of Medicine, Zagazig University.
  • Department of Internal Medicine, Faculty of Medicine, Zagazig University.
  • Department of Clinical Pathology, Faculty of Medicine, Zagazig University.
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Introduction: Cognitive impairment and glucose intolerance are prevalent in obese subjects. Irisin, a recently identified modifier of cognitive functions and glucose metabolism, was reported to be induced by physical exercise. We examined the association of exercise-induced irisin levels with improved cognitive functions and glucose metabolism in both obese and normal weight subjects. Subjects and Methods: 120 subjects, both males and females, comprised of 60 obese and 60 normal-weight subjects were undergone supervised active aerobic exercises for 3-months. Irisin levels, cognitive functions, fasting blood glucose, insulin, homeostatic model assessment of insulin resistance index (HOMA-IR) were assessed at the initiation and termination of the study. Results: Obese subjects demonstrated lower irisin levels, impaired cognitive functions and higher insulin as well as HOMA-IR levels compared to the normal weight group. Physical exercise induced significant upregulation of irisin levels together with improvement of cognitive functions and significant reduction of insulin and HOMA-IR levels in both groups. Exercise-induced irisin levels demonstrated significant positive correlations with improved cognitive functions and significant negative correlation with insulin level and HOMA-IR. Conclusion: Physical exercise improves cognitive functions and glucose metabolism. Our results suggest that irisin could be an important molecular mediator and therapeutic target for improving cognitive functions and glucose metabolism.

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[Nahed Shehta, *Ahmed F. Elsaid, Nadine Ahmad Raafat, AbeerAlbiomyKhalefa, Ghada M. Samir and Saffa M. El Alawi. (2017); PHYSICAL EXERCISE INDUCES IRISIN LEVELS ASSOCIATED WITH IMPROVED COGNITIVE FUNCTIONS AND GLUCOSE TOLERANCE IN OBESE AND NORMAL WEIGHT EGYPTIAN SUBJECTS: A 3-MONTH INTERVENTIONAL STUDY. Int. J. of Adv. Res. 5 (Aug). 2025-2035] (ISSN 2320-5407). www.journalijar.com

Nahed shehta
Department of Neurology, Faculty of Medicine, Zagazig University

DOI:

Article DOI: 10.21474/IJAR01/5269      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5269

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