DESIGN OF MEDICATED TOOTH PASTE FOR DENTAL DISORDERS.

In the present work, it was planned to prepare therapeutic medicated dental pastes for treatment of periodontitis and oral thrush, which provides effective treatment. Stress was given on local action of the drug and to treat initial stages of periodontitis and oral thrush. Beclomethasonedipropionate was chosen model drug which was a corticosteroid which has a wide range of anti-inflammatory activity. The prepared dental pastes were subjected for various physicochemical parameters like PH, Spreadability, tube extrudability, uniformity of drug content and IR studies. For this study periodontal infective pus sample of a patient collected from a patient under the supervision of dental professor of a local dental college. In-vitro drug release studies were carried out in PH 6.4 phosphate buffer. Stability studies of selected formulations were also done at ambient temperature (30?C) for the period of six months as per ICH guidelines. The formulations were subjected for primary skin irritation test in healthy human volunteers for 72 hours. In-vitro diffusion study showed good results in formulation F2, which showed more retentive time in oral cavity. During physicochemical studies significant results were obtained and found to be within the limits of official standards. The present work is being focused on designing of medicated tooth pastes to protect the gums, teeth and oral cavity from periodontal infections and oral thrush resulting from improper fixation of artificial dentures. The present study revealed that the prepared Beclomethasonedipropionate dental paste formulations will be useful in the treatment of oral thrush and periodontal diseases of all age groups of patients.