OBSTRUCTIVE JAUNDICE- INDUCED SINUS BRADYCARDIA IN CHILD WITH SICKLE CELL DISEASE.

  • Hematology/ Oncology department, King Fahd Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia.
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Sinus bradycardia is a rare condition in healthy children. Different causes of bradycardia in pediatrics listed in literature for more than fifty years ago. Obstructive jaundice has been strongly linked to sinus bradycardia. Multiple studies on animals initiated to discover the possible underling mechanism. collectively, bile acid considers as the key role of obstructive jaundice induced bradycardia but other factors emerged including nitric oxide, endogenous opioids, TNF-α and atrial natriuretic pedtide (ANP). No sufficient data found in the literature about the exact mechanism of bradycardia and cholestasis on human subjects specially pediatrics so, in this paper we report an 11 year old girl who diagnosed with obstructive jaundice and sinus bradycardia.

  1. Moyer V, Freese DK, Whitington PF, Olson AD, Brewer F, Colletti RB, et al. Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of pediatric gastroenterology and nutrition. 2004;39(2):115-28.
  2. Rosenthal P, Blanckaert N, Kabra PM, Thaler MM. Formation of bilirubin conjugates in human newborns. Pediatric research. 1986;20(10):947-50.
  3. Kugler JD. Sinus node dysfunction. Progress in Pediatric Cardiology. 1994;3(4):226-35.
  4. Premkumar S, Sundararajan P, Sangaralingam T. Clinical Profile of Cardiac Arrhythmias in Children Attending the Out Patient Department of a Tertiary Paediatric Care Centre in Chennai. Journal of clinical and diagnostic research: JCDR. 2016;10(12):SC06.
  5. Kirk JE, Kvorning SA. SINUS BRADYCARDIA A CLZNICAL STUDY OF 515 CONSECUTIVE CASES. Journal of Internal Medicine. 1952;142(S266):625-52.
  6. Song E, Segal I, Hodkinson J, Kew M. Sinus bradycardia in obstructive jaundice--correlation with total serum bile acid concentrations. South African medical journal= Suid-Afrikaanse tydskrif vir geneeskunde. 1983;64(14):548-51.
  7. Bashour TT, Antonini C, Fisher J. Severe sinus node dysfunction in obstructive jaundice. Annals of internal medicine. 1985;103(3):384-5.
  8. Moezi L, Dehpour AR. Cardiovascular abnormalities in obstructive cholestasis: the possible mechanisms. Liver International. 2013;33(1):7-15.
  9. Kotake H, Itoh T, Watanabe M, Hisatome I, Hasegawa J, Mashiba H. Effect of bile acid on electrophysiological properties of rabbit sino‐atrial node in vitro. British journal of pharmacology. 1989;98(2):357-60.
  10. Smith TW, Balligand J-L, Kaye DM, Wiviott SD, Simmons WW, Han X, et al. The role of the NO pathway in the control of cardiac function. Journal of cardiac failure. 1996;2:S141-S7.
  11. Seki T, Hagiwara H, Naruse K, Kadowaki M, Kashiwagi M, Demura H, et al. In SituIdentification of Messenger RNA of Endothelial Type Nitric Oxide Synthase in Rat Cardiac Myocytes. Biochemical and biophysical research communications. 1996;218(2):601-5.
  12. Tu W, Kitade H, Satoi S, Zhang ZT, Kaibori M, Kwon A-H, et al. Increased nitric oxide production in hepatocytes is involved in liver dysfunction following obstructive jaundice. Journal of Surgical Research. 2002;106(1):31-6.
  13. Mani AR, Nahavandi A, Moosavi M, Safarinejad R, Dehpour AR. Dual nitric oxide mechanisms of cholestasis‐induced bradycardia in the rat. Clinical and experimental pharmacology and physiology. 2002;29(10):905-8.
  14. Nahavandi A, Dehpour AR, Mani AR, Homayounfar H, Abdoli A, Abdolhoseini MR. The role of nitric oxide in bradycardia of rats with obstructive cholestasis. European journal of pharmacology. 2001;411(1):135-41.
  15. Gaskari SA, Mani AR, Ejtemaei‐Mehr S, Namiranian K, Homayoun H, Ahmadi H, et al. Do endogenous opioids contribute to the bradycardia of rats with obstructive cholestasis? Fundamental & clinical pharmacology. 2002;16(4):273-9.
  16. Kwok EH, Dun NJ. Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats. Brain research. 1998;803(1):204-7.
  17. Al Talhi Y, Shirah BH, Altowairqi M, Yousef Y. Laparoscopic cholecystectomy for cholelithiasis in children with sickle cell disease. Clinical Journal of Gastroenterology. 2017:1-7.

[Housam Y. Almadani, Shahad A. Alansari and Banan I. Alsaied. (2017); OBSTRUCTIVE JAUNDICE- INDUCED SINUS BRADYCARDIA IN CHILD WITH SICKLE CELL DISEASE. Int. J. of Adv. Res. 5 (Oct). 1172-1175] (ISSN 2320-5407). www.journalijar.com

Shahad A. Alansari

DOI:

Article DOI: 10.21474/IJAR01/5635      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5635

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