22Aug 2017

ASSESSMENT OF GLUTATHIONE REDUCTASE(GR) AND GLUTATHIONE PEROXIDASE(GPX) IN ARTHRITIC AND DIABETIC PATIENT RISK OF URINARY INCONTINENCE.

  • Department of Life sciences,Techno India University,EM 4 Saltlake,Sector v,Kolkata-700091,India.
  • OPTM Research Institute,145Rashbehari Avenue,Kolkata-700029,India.
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Background:Urinary incontinence,involuntary urination,is any leakage of urine.It can be a common and distressing problem,which may have a profound impact on quality of life.Different risk factors are associated with urinary incontinence. Diabetes and arthritis are the major risk factors of urinary incontinence. Free radicals are produced during inflammation and hyperglycemia state as a result oxidative stress occurs during diabetes and arthritis. Aim and objectives:The aim of the present study was to evaluate the activity of two oxidative stress marker such as glutathione reductase and glutathione peroxidase in diabetes and arthritis patient risk of UI. Materials and methods:The study protocol and all recruitment materials were approved by the ethical board and study was carried out 40 diabetic,40 arthritic patients and 20 healthy control,taken from OPTM Research Institute,145 Rashbehari Avenue,Kolkata-700029,India.Then oxidative stress marker enzymes GR and GPx activity were evaluated. Results:It was observed that GR activity of diabetic and arthritic patients in all age groups showed a higher statistical significant as compaired to healthy controls(p<0.001,p<0.01) and in two separate age groups(<50 years old and >50 years old),showed a higher statistical significant as compaired to healthy controls(p<0.01,p<0.001,p<0.01,p<0.05).Besides GPx activity was observed in diabetic and arthritic patients in all age groups and there was a higher statistical significant of arthritic patients as compaired to healthy controls(p<0.001) and statistically not significant of diabetic patients as compaired to healthy controls with all age groups and <50 years old age groups(p=0.0002,p=0.0021) and statistically significant as compaired to healthy controls with >50 years old age group(p<0.001). Conclusion:This study revealed that glutathione radical is activated by glutathione enzyme during disease state and GR and GPx are good oxidative stress markers for evaluation in diabetes and arthritis.risk of UI.

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[Jubilee Hatai, Apurba Ganguly, SudipK Banerjee and Beauty Hatai. (2017); ASSESSMENT OF GLUTATHIONE REDUCTASE(GR) AND GLUTATHIONE PEROXIDASE(GPX) IN ARTHRITIC AND DIABETIC PATIENT RISK OF URINARY INCONTINENCE. Int. J. of Adv. Res. 5 (Aug). 1350-1356] (ISSN 2320-5407). www.journalijar.com

Jubilee Hatai
Department of Biochemistry,Techno India University,EM 4 Saltlake,Sector v,Kolkata-700091,India

DOI:

Article DOI: 10.21474/IJAR01/5189      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5189

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