Vol. 5 (09) pp. 1020-1035 DOI: 10.21474/IJAR01/5419

CLINICOPATHOLOGICAL SIGNIFICANCE OF FASCIN1 AND Β-CATENIN EXPRESSION IN COLORECTAL ADENOCARCINOMA; AN IMMUNOHISTOCHEMICAL STUDY"

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  • Pathology Department, Faculty of medicine, Zagazig University, Egypt.
  • General surgery Department, Faculty of medicine, Zagazig University, Egypt.
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Abstract

Background: Colorectal cancer (CRC) is the fourth most common human malignancies worldwide. Fascin1 is an actin bundling protein along the entire length of filopodia and its diminution leads to reduction in the number of filopodia. Beta-catenin (β-catenin) is one of the catenin protein family, involved in the regulation of adhesion between the cells and gene transcription. It is one of the cadherin protein complexes acting as intracellular signal transducer in the Wnt signaling pathway. Objective: we aimed in this study to investigate the immunohistochemical expression of FascinI and β- catenine incancer colon and correlate their expression with other clinicopathologic features. Material and methods: 45cases of colorectal adenocarcinoma and 30 cases of adenomatous polyp were collected from Pathology Department. Faculty of Medicine. Zagazig University between January 2013 to December 2016, using immunohistochemical antibodies to Fascin 1 and β- catenine. Results: positive Fascin1 expression was observed in 31.1%) and 40% of CRC and colorectal adenomatous polyp respectively. Positive β- catenineimmunohistochemicalstaining (IHC) where 35.6% and 40% CRC and colorectal adenomatous polyp. The expression of cytoplasmic β - catenin protein in CRCwas significantly (p=0.0001) higher than in the adenomatous polyp. Both markers are significantly correlated with tumor grade (p<<0.001). No significant association between (IHC) staining was found between both markers expression and N stage of tumor. Expressions of both of them were significantly positively correlated with each other (p<0.001). Conclusion: Fascin 1 has known roles in cell morphology and migration and may represent a potential novel marker or therapeutic target for patients with colorectal cancer.Fascin1is regulated byβ - catenine. IHC staining of β-catenin is considered a useful marker to predict the prognosis in colorectal cancer (CRC). Keywords: Fascin1; Bcatenin; colorectal cancer; immunohistochemistry; prognosis

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How to Cite This Article

Hanaa A. Atwa, Abeer M. AbdElbary, Taha A Baiomy and Yasser A. Orban. (2017); CLINICOPATHOLOGICAL SIGNIFICANCE OF FASCIN1 AND Β-CATENIN EXPRESSION IN COLORECTAL ADENOCARCINOMA; AN IMMUNOHISTOCHEMICAL STUDY", Int. J. of Adv. Res., 5 (09), 1020-1035, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/5419

Corresponding Author

Abeer M. AbdElbary1
Lecturer of Pathology Department, Faculty of medicine, Zagazig University, Egypt.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.