ORAL TOXICITY STUDY OF KARANJA SEED CHURANA (PONGAMIA PINNATA PIERRE) ON ALBINO RATS.
- Lecturer P.G. Deptt. Of Dravyaguna, R.G.G.P.G.AYU.College, Paprola.
- Professor & H.O.D., P.G. Deptt. Of Dravyaguna, R.G.G.P.G.AYU. College, Paprola.
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The acute toxicity studies of crude seed suspension of Pongamia Pinnata was studied in Charles Foster strain albino mice. The studies included the gross observation such as changes in body weight, ponderal changes in liver and heart; spleen and kidney were observed. Haematological and histopathological studies were also done. Rats are grouped as 6 rats in each group. The rats treated with suspension Karanja seed churana (Pongamia pinnata powder) orally with dose of 1600mg/kg body weight daily for 20 days and observed for any toxicity. On 21st day, rats are sacrificed and blood samples and organs were sent to laboratory for various studies. The test drug did not produce significant toxic effect on the organs mentioned but mild to moderate pathological changes were observed in spleen and liver, but these changes are not severe. All the haematolological parameters were non-significant except haemoglobin percentage which was highly significant in comparison to control group. It is proved that the test drug is safe for human use at this dose but should be administered cautiously in impaired liver functions.
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[Gupta Chandni and Upadhayaya Ashwani. (2017); ORAL TOXICITY STUDY OF KARANJA SEED CHURANA (PONGAMIA PINNATA PIERRE) ON ALBINO RATS. Int. J. of Adv. Res. 5 (Oct). 159-168] (ISSN 2320-5407). www.journalijar.com
