A COMPARATIVE STUDY BETWEEN PREOPERATIVE USE OF MISOPROSTOL AND DINOPROSTONE FOR REDUCTION OF HEMORRHAGE DURING ABDOMINAL MYOMECTOMY.

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Aim of work: is to compare the effect of a single preoperative dose of vaginal prostaglandin E1 (misoprostol 400 ug) versus vaginal Prostaglandin E2 (PGE2; dinoprostone 20mg) suppository on reducing intraoperative blood loss and the need for subsequent blood transfusion during abdominal myomectomy for symptomatic leiomyomas. Patients and methods: The study included 93 women undergoing abdominal myomectomy for symptomatic uterine myoma after complete counseling, and the patients were randomized by random method into three groups. Result: There was statistical high significant difference between preoperative and postoperative hemoglobin changes in group A, group B and group C. There was statistical high significant difference between preoperative and postoperative Hct changes in group A, group B and group C. Conclusion:The use of vaginal misoprostol or dinoprostone is an effective method to reduce intraoperative hemorrhage during abdominal myomectomy. Also, a single, preoperative dose of dinoprostone administered intravaginally could be safe and reliable method to help decrease blood loss during abdominal myomectomy.

  1. Buttram, V.C. and Reiter, R.C. (2008):Uterine leiomyomas: Etiology, symptomatology, and management. Fertil Steril; 36: 433-45.
  2. Aronson JK (2009): Meyler's Side Effects of Endocrine and Metabolic Drugs; Prostaglandins; 101-135.
  3. Blanchard K, Clark S, Winikoff B, et al. (2002): Misoprostol for women?s health: a review. Obstetrics and Gynecology; 99(2): 316-332.
  4. Blanchard K, Shelley C, Beverly W, et al. (2002): Misoprostol for Women?s health vol. 99, no. 2, American College of Obstetricians and Gynecologists; 316-22.
  5. Carbonell Esteve JL, Acosta R, Heredia B, et al. (2008): Mifepristone for the treatment of uterine leiomyomas: a randomized controlled trial. Obstet Gynecol; 112: 1029?36.
  6. Goldberg AB, Greenberg MB, Darney PD (2001): Misoprostol and pregnancy. New England Journal of Medicine; 344(1): 38?47.
  7. Kongnyuy EJ and Wiysonge CS (2011): Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database of Systematic Reviews; 11: CD005355.
  8. Kongnyuy EJ, Wiysonge CS (2007): Interventions to reduce hemorrhage during myomectomy for fibroids. Cochrane Database of systemic Reviews; Issue I. Art. No.: CD005355.
  9. Ginsburg ES, Benson CB, Garfield JM, et al. (1993): The effect of operative technique and uterine size on blood loss during myomectomy: a prospective randomized study]. Fertil Steril; 60: 956-62.
  10. Kongnyuy EJ & Wiysonge CS (2008): Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev; 1: CD005355.
  11. Friedman AJ, Harrison-Atlas D, Barbieri RL (2009):A randomized, placebo-controlled, double-blind study evaluating the efficacy of leuprolide acetate depot in the treatment of uterine leiomyomata. Fertil Steril; 51(2): 251-6.
  12. Celik H, Sapmaz E (2003): Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy. Fertil Steril; 79(5): 1207-10
  13. El-Shabrawy A, Abo Elwan Y and Kotb M (2003): Use of misoprostol in abdominal myomectomy. Ain Shams Medical Journal; 54(10): 1489-1497.
  14. Shokeir T, Shalaby H, Nabil H, et al. (2013): Reducing blood loss at abdominal myomectomy with preoperative use of dinoprostone intravaginal suppository: A randomized placebo-controlled pilot study. European Journal of Obstetrics and Gynecology and Reproductive Biology; 166: 61-63.
  15. Kongnyuy EJ and Wiysonge CS (2014): Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev; 8: CD005355.
  16. Chan LY (2004):Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy. Fertil Steril; 81: 1060-1061.
  17. Kalogiannidis I, Xiromeritis P, Prapas N, Prapas Y(2011): Intravaginal misoprostol reduces intraoperative blood loss in minimally invasive myomectomy: a randomized clinical trial.? Clin Exp Obstet Gynecol; 38: 46?49.
  18. Frederick S, Frederick J, Fletcher H et?al (2013). A trial comparing the use of rectal misoprostol plus perivascular vasopressin with? perivascular vasopressin alone to decrease myometrial bleeding at the? time of abdominal myomectomy. FertilSteril; 100: 1044?1049
  19. Engman M, Granberg S, Williams AR, et al. (2009): Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trial. Hum Reprod; 24: 1870?9.
  20. Chai J, Hon E, Li CF et?al (2011). A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy.Eur J ObstetGynecolReprodBiol; 158: 72?75.
  21. Biswas J, Chaudhuri P, Mandal A et?al (2013). Effect of a single preoperative dose of sublingual misoprostol on intraoperative blood loss during total abdominal hysterectomy. Int J Gynecol Obstet; 122: 244?247.

[El-Sayed A. El-Naggar, Youssef A. El-Sayed, Walid A. Mohamed, Essa M. Arfa and Engy M. El-Sagheer. (2017); A COMPARATIVE STUDY BETWEEN PREOPERATIVE USE OF MISOPROSTOL AND DINOPROSTONE FOR REDUCTION OF HEMORRHAGE DURING ABDOMINAL MYOMECTOMY. Int. J. of Adv. Res. 5 (Oct). 291-298] (ISSN 2320-5407). www.journalijar.com

El-Sayed A. El-Naggar

DOI:

Article DOI: 10.21474/IJAR01/5532      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5532

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