ROLES OF LARGE TUMOR SUPPRESSOR GENES IN BREAST CANCER.

  • Professor, Department of Breast and Thyroid Surgery, Shanghai 10th People?s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Jing?an District, Shanghai 200072, P.R. China.
  • Resident, Department of Breast and Thyroid Surgery, Shanghai 10th People?s Hospital, Tongji University School of Medicine, 301 Yanchang Road, Jing?an District, Shanghai 200072, P.R. China.
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The Hippo pathway is a tumor suppressor pathway that negatively regulates YAP and TAZ by regulating cell proliferation, cell growth and cell death. One of the core kinase of Hippo pathway, large tumor suppressor (LATS 1/2) are serine/threonine kinases which belongs to NDR family that are phosphorylated and activated by MST 1/2 and MOB 1/2 followed by phosphorylation of transcriptional co-activator YAP. Originally, isolated from Drosophila as tumor suppressor genes recently isolated from mice and human. Since a decade, there has been various studies in Hippo pathway but little is known about LATS expression in breast cancers. Hence, in this review we interpret the role of LATS in breast cancer and its significance as tumor suppressor gene.

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Fang LIN and Munankarmy AMIK. (2017); ROLES OF LARGE TUMOR SUPPRESSOR GENES IN BREAST CANCER., Int. J. of Adv. Res., 5 (11), 954-958, ISSN 2320-5407. DOI URL: https://dx.doi.org/10.21474/IJAR01/5854

Fang Lin
Tongji University, School of Medicine

DOI:

Article DOI: 10.21474/IJAR01/5854      
DOI URL: https://dx.doi.org/10.21474/IJAR01/5854

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