Vol. 6 (02) pp. 287-300 DOI: 10.21474/IJAR01/6439

REVIEW ON: RECENT ADVANCES IN THE STATE OF THE ART OF IN SITU FORMING INJECTABLE HYDROGEL SYSTEMS FOR THERAPEUTIC APPLICATIONS.

, and
  • 1Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-781017 (Affiliated to Assam Science and Technology University, Jalukbari, Guwahati-781013).
33 Downloads 204 Views
Crossref

Download Full Paper (PDF)

Abstract

In situ injectable gelling systems have been extensively investigated with the aim of being applied for minimally invasive drug delivery or injectable tissue engineering. This article explores the injectable in-situ gelling system for prolonged release parenteral drug delivery system and their strategies of preparation. Here, we describe in situ-forming injectable hydrogel systems, prepared usinga variety of chemical cross linkers or physical interactions, for application in drug delivery. There are many newer approaches for in situ injectable hydrogels that can be delivered in minimally invasive techniques such as injection, ocular or nasal administration while protecting drugs or cells from the hostile environment. Recently, the Michael addition reaction between thiol and vinyl groups, the click reaction between bis (yne) molecules and multi arm azides, and the Schiff base reaction have been investigated for generation of injectable hydrogels, due to the high selectivity and biocompatibility of these reactions. Non-covalent physical interactions have also been proposed as cross linking mechanisms for in situ forming injectable hydrogels. Hydrophobic interactions, ionic interactions, stereo-complex formation, complementary pair formation, and host-guest interactions drive the formation of 3D polymeric networks. In particular, supramolecular hydrogels have been developed using the host-guest chemistry of cyclodextrin (CD), which allows highly selective, simple, and biocompatible cross linking. Finally, we review the current state of the art of injectable hydrogel systems for application in drug delivery, cell therapy and tissue regeneration.

Keywords

How to Cite This Article

Runa Chakravorty, Bipul Nath and Sumit Das. (2018); REVIEW ON: RECENT ADVANCES IN THE STATE OF THE ART OF IN SITU FORMING INJECTABLE HYDROGEL SYSTEMS FOR THERAPEUTIC APPLICATIONS., International Journal of Advanced Research (IJAR), 6 (02), 287-300, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/6439

Corresponding Author

RUNA CHAKRAVORTY
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-

Article Analytics

References

  1. Fakhari A, Subramony JA: Engineered in-situ depot-forming hydrogelsfor intratumoral drug delivery. Journal of controlled release 2015; 220:465?475.
  2. Kempe S, Mader K: In situ forming implants- an attractive formulation principle for parenteral depot formulations. Journal of Controlled Release 2012; 161:668?679.
  3. Almeida H, Amaral MH, Lobao P and Lobo JM: In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations. Drug Discovery Today 2014; 19:400?412.
  4. Wang XQ, Liu GY, Ma JL, Guo?S, Gao?L, Jia?Y, Li?X and Zhang?Q: In situ gel-forming system: an attractive alternative for nasal drug delivery. Critical Review Therapy Drug Carrier System.2013; 30(5):411-34.
  5. Russo T, Tunesi M, Giordano C, Gloria A and Ambrosio L: Hydrogels for central nervous system therapeutic strategies. Process Instrumentation Mechanical Engineering Hydrogel 2015; 229:905?916.
  6. Li Y, Rodrigues J, & Tom?s H: Injectable and biodegradable hydrogels: Gelation, biodegradation and biomedical applications. Chemical Society Reviews, 41(6), 2193?2221.
  7. Choi SM, Lee Y, Son JY, Bae J W, Park KM, & Park KD: Synthesis and characterization of in situ gellable poly (glycerol sebacate)-co-poly(ethylene glycol) polymers. Macromolecular Research 2017; 25(1): 85?91.
  8. Bae KH, Wang LS, & Kurisawa M: Injectable biodegradable hydrogels: Progress and challenges. Journal of Materials Chemistry 2013;1(40): 5371.
  9. Panyam J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Advanced Drug Delivery 2003; 55: 329?347.
  10. Bannon-Peppas L, Blanchette JO: Nanoparticle and targeted system for cancer therapy. Advanced Drug Delivery 2004; 56:1649?1659.
  11. Barraud L, Merle P, Soma E, Lefrancois L, Guerret S, Chevallier M, Dubernet C, Couvreur P, Trepo C and Vitvitski L : Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo. journal of Hepatology 2005; 42(5): 736?743.

12.??? Kakinoki S,? Yasuda C, Kaetsu I, Uchida K, Yukutake K,? Nakayama M, Fujiie S, Kuroda D, Kato M, and Ohyanagi H: Preparation of poly-lactic acid microsphere containing the angiogenesis inhibitor TNP-470 with medium-chain triglyceride and the in vitro evaluation of release profiles. European Journal of Pharmaceutics and Biopharmaceutics 2003; 55:155?160.

  1. Freiberg S, Zhu X: Polymer microsphere for controlled drug release. International Journal of Pharmaceutics 2004; 282: 1?18.
  2. Nishiyama N, Bae Y, Miyata K, Fukushima S, Kataoka K: Smart polymeric micelles for gene and drug delivery. Drug Discovery Today 2005; 2:21?26.
  3. Hruby M, Konak C, Ulbrich K: Polymeric micellar pH-sensitive drug delivery system for doxorubicin. Journal of Controlled Release 2005; 103:137?148.
  4. Goyal P, Goyal K, Kumar S.G, Singh A, Katare OP, Mishra DN : Liposomal drug delivery systems ? clinical applications. Acta Pharmaceutica 2005; 55:1?25.
  5. Kaneda Y: Virosomes: Evoluation of the liposome as a targeted drug delivery system, Advanced Drug Delivery Reviews 2000; 43: 197?205.
  6. Saul JM, Annapragada A, Natarajan JV, and Bellamkonda RV: Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. Journal of Controlled Release 2003; 92: 49?67.
  7. He H, Cao X, Lee LJ: Design of a novel hydrogel-based intelligent system for controlled drug release. Journal of Controlled Release 2004; 95: 391-402.
  8. Hoffman AS: Hydrogels for biomedical applications. Advanced Drug Delivery Reviews. 2002; 54:3?12.
  9. Packhaeuser CB, Schnieders J, Oster CG, Kissel T: In situ forming parenteral drug delivery systems: an overview. European Journal of pharmaceutics and Biopharmaceutics 2004; 58: 445?455.
  10. Ibusuki S, Fuji Y, Iwamoto Y, Matsuda T: Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin: fabrication and in vitro performance. Tissue Engineering 2003; 9:371?384.
  11. Malmsten M, Lindman B: Self-assembly in aqueous block copolymer solutions,Macromolecules 1992; 25 :5440?5445.
  12. Gariepy E.R., Leroux J.C: In situ-forming hydrogels review of temperature-sensitive systems. European Journal of pharmaceutics and Biopharmaceutics 2004; 58: 409?426.
  13. Draget K.I., Br?k K.I., and Smidsr?d O: Alginate based new materials. International. Journal of Biological Macromolecules 1997; 21:47?55.
  14. Lee KY, Mooney DJ: Hydrogels for tissue engineering. Chemical Reviews. 2001; 101:1869?1879.
  15. Sultzbaugh KJ, Speaker TJ: A method to attach lectins to the surface of spermine alginate microcapsules based on the avidin biotin interaction. Journal of Microencapsulation 1996 13:363?376.
  16. Rowley JA, Madlambayan G and Mooney DJ: Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1990; 20: 45?53.
  17. Norouzi M, Nazari B and Miller DW: Injectable hydrogel-based drug delivery systems for local cancer therapy, Drug Discovery Today. 21: 1835-1847.
  18. Patil PR, Shaikh SS, Shivsharan KJ and Shahi SR: In situ gel: a novel drug delivery system. Indo American Journal of Pharmaceutical Research 2014; 11: 5406-5413.
  19. Fakhari A. and Subramony JA: Engineered in-situ depot-forming hydrogels for intratumoral drug delivery .Journal of Controlled Release 2015; 220:465?475.
  20. Mak? A., Cs?ka G, P?sztor E, Marton S, Horvai G and Klebovich I: Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation. European Journal of Pharmaceutics and Biopharmaceutics 2009; 72: 260?265.
  21. Madan M, Bajaj A, Lewis S, Udupa N. and Baig J. A.; In Situ Forming Polymeric Drug Delivery Systems. Indian Journal of? Science 2009; 71 (3): 242-251.
  22. Hatefi A, Amsden B; Biodegradable injectable in situ forming drug delivery systems. Journal of Controlled Release 2002; 80: 9?28.
  23. Packhaeuser CB, Schnieders J, Oster CG, kissel T: In-situ forming parenteral drug delivery system: an overview. European journal of pharmaceutics and biopharmaceutics 2004; 58:445-455.
  24. Berger J, Reist M, Mayer JM, Felt O, Peppas N, Gurny R : Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics 2004; 57: 19?34.
  25. Hatefi A, Amsden B: Biodegradable injectable in situ forming drug delivery systems; Journal of Controlled Release 2002; 80: 9?28.
  26. Matschke C, Isele U, Van Hoogevest P, and Fahr A. Sustained release injectables formed in situ and their potential use for veterinary products. Journal of Control Release 2002; 85:1-15.
  27. Chaocheng Lu a, Mengjiao Liu a, Hualin Fu a, Wei Zhang a, Guangneng Peng b, Yanli Zhang a, Hang Cao a, Li Luo; Novel thermosensitive in situ gel based on poloxamer for uterus delivery. European Journal of Pharmaceutical Sciences 2015; 77:24?28.
  28. Weinberg B.D., Blanco E., Gao J: Polymer implants for intratumoral drug delivery and cancer therapy. Journal of Pharmaceutical Science.2008; 97:1681?1702.
  29. Crawford J, Dale D.C., Lyman G.H.: Chemotherapy-induced neutropenia. Cancer 2004; 100:228?237.
  30. Miyazaki S., Aoyama H, Kawasaki N, Kubo W, Attwood D: In-situ gelling gellan formulations as vehicles for oral drug delivery. Journal of Controlled Release 1999; 60:287-295.
  31. Mather BD, Viswanathan K, Miller KM, Long TE: Michael addition reactions in macromolecular design for emerging technologies. Progress in Polymer Science 2006; 31:487?531.
  32. Zheng Shu X, Liu Y, Palumbo FS, Luo Y, Prestwich GD. In situ crosslinkable hyaluronan hydrogels for tissue engineering. Biomaterials 2004; 25:1339?1348.
  33. Jin R, Moreira Teixeira LS, Krouwels A, Dijkstra PJ, van Blitter-swijk CA, Karperien M, Feijen J: Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: an injectable biomaterial for cartilage repair. Acta Biomateriala 2010; 6:1968.
  34. Tae G, Kim YJ, Choi WI, Kim M, Stayton PS, Hoffman AS: Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules. Biomacromolecules 2007; 8:1979?1986.
  35. Kim M, Lee JY, Jones CN, Revzin A, Tae G. Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes. Biomaterials 2010; 31:3596?603.
  36. Yang JA, Kim H, Park K, Hahn SK: Molecular design of hyaluronic acid hydrogel networks for long-term controlled delivery of human growth hormone. Soft Matter 2011; 7:868?70.
  37. Cai S, Liu Y, Zheng SX, Prestwich GD: Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growthfactor. Biomaterials 2005; 26:6054?67.
  38. Liu Y, Shu XZ, Prestwich GD: Reduced postoperativeintra-abdominal adhesions using Carbylan-SX, a semisynthetic gly-cosaminoglycan hydrogel. Fertil Steril 2007; 87:940?8.
  39. Shu XZ, Liu Y, Palumbo F, Prestwich GD: Disulfide-crosslinked hyaluronan?gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth. Biomaterials2003; 24:3825?34.
  40. Binder WH, Sachsenhofer R.: ?Click? chemistry in polymer and materials science. Macromolecular Rapid Communications 2007; 28:15?54.
  41. Nimmo CM, Shoichet MS: Regenerative biomaterials that ?click?: simple, aqueous-based protocols for hydrogel synthesis, surface immobilization, and 3D patterning. Bioconjugate Chemistry 2011; 22:2199?209.
  42. Van Dijk M, van Nostrum CF, Hennink WE, Rijkers DT, Liskamp RM: Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry Biomacromolecules 2010; 11:1608?14.
  43. Malkoch M, Vestberg R, Gupta N, Mespouille L, Dubois P, Mason AF, Hedrick JL, Liao Q, Frank CW, Kingsbury K, Hawker CJ: Synthesis of well-defined hydrogel networks using click chemistry. Chemical Communication 2006:2774?6.
  44. Johnson JA, Lewis DR, Diaz DD, Finn MG, Koberstein JT, Turro NJ: Synthesis of degradable model networks via ATRP and click chemistry. Journal of the American Chemical Society 2006; 128:6564?5.
  45. DeForest CA, Anseth KS: Cytocompatible click-based hydro-gels with dynamically tunable properties through orthogonal photo conjugation and photo cleavage reactions. Nature Chemistry 2011; 3:925?31.
  46. DeForest CA, Polizzotti BD, Anseth KS: Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments. Nature Materials 2009; 8:659?64.
  47. Ossipov DA, Brannvall K, Forsberg-Nilsson K, Hilborn J: Formation of the first injectablepoly(vinyl alcohol) hydrogel by mixing of functional PVA precursors. Journal of Appllied Polymer Science 2007; 106:60?70.
  48. Tan H, Chu CR, Payne KA, Marra KG; Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials 2009; 30:2499?506.
  49. Wang DA, Varghese S, Sharma B, Strehin I, Fermanian S, Gorham J,Fairbrother DH, Cascio B, Elisseeff JH. Multifunctional chondroitin sulphate for cartilage tissue?biomaterial integration. Nature Materials 2007; 6:385?92.
  50. Jia X, Yeo Y, Clifton RJ, Jiao T, Kohane DS, Kobler JB, Zeitels SM,Langer R; Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules 2006; 7:3336?44.
  51. Maia J, Ferreira L, Carvalho R, Ramos MA, Gil MH: Synthesis and characterization of new injectable and degradable dextran-based hydrogels. Polymer 2005; 46:9604?14.
  52. Kim KS, Park SJ, Yang JA, Jeon JH, Bhang SH, Kim BS, Hahn SK ; Injectable hyaluronic acid?tyramine hydrogels for the treatment of rheumatoid arthritis. Acta Biomateriala 2011; 7:666?74.
  53. Jin R, Moreira Teixeira LS, Dijkstra PJ, van Blitterswijk CA, Karperien M, Feijen J; Chondrogenesis in injectable enzymatically crosslinkedheparin/dextran hydrogels. Journal of Controlled Release 2011; 152:186?95.
  54. Jin R, Moreira Teixeira LS, Dijkstra PJ, Karperien M, van Blitter-swijk CA, Zhong ZY, Feijen J: Injectable chitosan-based hydrogels for cartilage tissue engineering. Biomaterials 2009; 30:2544?51.
  55. Elisseeff J, Anseth K, Sims D, McIntosh W, Randolph M, Langer R: Transdermal photopolymerization for minimally invasive implantation. Proceedings of the National Academi of Science USA 1999; 96:3104?7.
  56. Chou AI, Akintoye SO, Nicoll SB; Photo-crosslinked alginate hydro-gels support enhanced matrix accumulation by nucleus pulposuscells in vivo. Osteoarthr Cartil 2009; 17:1377?84.
  57. Pereira IHL, Ayres E, Patricio PS, Goes AM, Gomide VS, Junior EP, Orefice RL. Photopolymerizable and injectablepolyurethanes for biomedical applications: synthesis and biocompatibility. Acta Biomaterials 2010; 6:3056?66.
  58. Ovsianikov A, Malinauskas M, Schlie S, Chichkov B, Gittard S,Narayan R, Lobler M, Sternberg K, Schmitz KP, Haverich A: Three-dimensional laser micro- and nano-structuring of acrylatedpoly(ethylene glycol) materials and evaluation of their cytoxicity for tissue engineering Acta Biomateial 2011; 7:967?74.
  59. Williams CG, Malik AN, Kim TK, Manson PN, Elisseeff JH: Variable cytocompatibility of six cell lines with photo initiators used for polymerizing hydrogels and cell encapsulation. Biomaterials 2005; 26:1211?8.
  60. Stevens MM, Qanadilo HF, Langer R and Shastri VP: A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering. Biomaterials 2004; 25:887?94.
  61. Ashton RS, Banerjee A, Punyani S, Schaffer DV, Kane RS: Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials2007; 28:5518?25.
  62. Zhao LA, Weir MD, Xu HHK: An injectable calcium phosphate?alginate hydrogel?umbilical cordmesenchymalstem cell paste for bone tissue engineering. Biomaterials2010; 31:6502?10.
  63. Kuo CK, Ma PX: Ionically cross linked alginate hydrogels as scaf-folds for tissue engineering: part 1. Structure, gelation rate and mechanical properties. Biomaterials 2001; 22:511?21.
  64. Donati I, Asaro F, Paoletti S: Experimental evidence of counter ion affinity in alginates: the case of nongelling ion Mg2+. Journal of Physical Chemistry B 2009;113:12877?86.
  65. Sun JY, Zhao X, Illeperuma WR, Chaudhuri O, Oh KH, Mooney DJ,Vlassak JJ and Suo Z: Highly stretchable and tough hydrogels. Nature2012; 6:489:133.
  66. Lee KY, Mooney and DJ: Alginate: properties and biomedical applications. Progress in Polymer Science 2012; 37:106?26.
  67. Igarashi T, Iwasaki N, Kawamura D, Tsukuda Y, Kasahara Y, TodohM, Tadano S,and Minami A: Therapeutic effects of intra-articular ultra-purified low endotoxin alginate administration on experimental osteoarthritis in rabbits. Cartilage 2012; 3:70?8.
  68. Berger J, Reist M, Mayer JM, Felt O and Gurny R: Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics 2004; 57:35?52.
  69. Molinaro G, Leroux JC, Damas J and Adam A: Biocompatibility of thermosensitivechitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials. Biomaterials 2002; 23:2717?22.
  70. Chenite A, Chaput C, Wang D, Combes C, Buschmann MD, Hoemann CD, Leroux JC, Atkinson BL, Binette F and Selmani A: Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Bio-materials 2000; 21:2155?61.
  71. Tan HP and Marra KG: Injectable biodegradable hydrogels for tissue engineeringapplications. Materials 2010; 3: 1746?67.
  72. Yan JH, Yang L, Wang GR, Xiao Y, Zhang BH and Qi NM: Biocompatibility evaluation of chitosan-based injectable hydrogels for the culturing mice mesenchymal stem cells in vitro. Journal of Biomaterials Applications 2010; 24:625?37.
  73. Klouda L, Mikos AG: Thermoresponsive hydrogels in biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics 2008; 68:34?45.
  74. Stile RA and Healy KE: Thermo-responsive peptide-modified hydrogels for tissue regeneration. Biomacromolecules 2001; 2:185?94.
  75. Ruel-Gariepy E and Leroux JC: In situ-forming hydrogels ? review of temperature-sensitive systems. European Journal of Pharmaceuticals and Biopharmaceutics 2004; 58:409?26.
  76. Alexandridis P, Zhou DL and Khan A: Lyotropic liquid crystallinity in amphiphilic block copolymers: temperature effects on phase behavior and structure for poly (ethylene oxide)-b-poly(propyleneoxide)-b-poly(ethylene oxide) copolymers of different composition. Langmuir 1996; 12:2690?700.
  77. Zhang XZ, Wu DQ, Sun GM, Chu CC. Novel biodegradable and thermosensitive Dex-AI/PNIPA. A hydrogel: Macromolecular Bioscience 2003; 3:87?91.
  78. Ha DI, Lee SB, Chong MS, Lee YM, Kim SY, Park YH: Preparation of thermoresponsive and injectable hydrogels based on hyaluronic acid and poly (N-isopropylacrylamide) and their drug release behaviors. Macromol Res 2006; 14:87?93.
  79. Feng L, Hao JY, Xiong CD, Deng XM: A novel biodegradable and thermosensitive polymer with PEG-analogue macromolecularstructure. Chemical Communications 2009; 29:4411?3.
  80. Fusco S, Borzacchiello A, Netti PA: Perspectives on: PEO?PPO?PEO triblock copolymers and their biomedical applications. Journal of Bioactive and Compatible Polymers 2006; 21:149?64.
  81. Jeong B, Bae YH, Kim SW: In situ gelation of PEG?PLGA?PEG triblock copolymer aqueous solutions and degradation thereof. Journal of Biomedical Material Research 2000; 50:171?7.
  82. Disthabanchong S, Radinahamed P, Stitchantrakul W, Hongeng S,Rajatanavin R: Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells. Kidney International 2007; 71:201?209.
  83. Liu H, Slamovich EB and Webster TJ: Less harmful acidic degradation of poly(lacticco-glycolic acid) bone tissue engineeringscaffolds through titania nanoparticle addition. International Journal of? Nanomedicine 2006; 1:541?545.
  84. Xu XD, Zhang XZ, Cheng SX, Zhuo RX, Kennedy JF: A strategy to introduce the pH sensitivity to temperature sensitive PNIPAAm hydrogels without weakening the thermosensitivity. Carbohydrate Polymers 2007; 68:416?23.
  85. Kim HK, Shim WS, Kim SE, Lee KH, Kang E, Kim JH, Kwon IC and Lee DS: Injectable in situ-forming /thermo-sensitive hydrogel for bone tissue engineering.Tissue Engineering 2009;15:923?33.
  86. Potta T, Chun C, Song SC: Dual cross-linking systems of functionally photo-cross-linkable and thermoresponsive polyphosphazene hydrogels for biomedical applications. Biomacromolecules 2010; 11:1741?53.
  87. Tai H, Howard D, Takae S, Wang W, Vermonden T, Hennink WE,Stayton PS, Hoffman AS, Endruweit A, Alexander C, Howdle SM, and Shakesheff KM: Photo-cross-linked hydrogels from thermoresponsivePEGMEMA?PPGMA?EGDMA copolymers containing multiple methacrylate groups: mechanical property, swelling, protein release, and cytotoxicity. Biomacromolecules 2009; 10:2895?903
  88. Salem AK, Rose FRAJ, Oreffo ROC, Yang XB, Davies MC, Mitchell JR, Roberts CJ, Stolnik-Trenkic S, Tendler SJB, Williams PM, Shakesheff KM: Porous polymer and cell composites that self-assemble in situ. Advanced Material 2003; 15:210?3
  89. Foo CTSWP, Lee JS, Mulyasasmita W, Parisi-Amon A, HeilshornSC: Two-component protein-engineered physical hydrogels for cell Proceedings of the National Academy of Sciences USA 2009; 106:22067?72.
  90. Kiick KL : Peptide- and protein-mediated assembly of heparinized hydrogels. Soft Matter 2008; 4:29?37.
  91. Miyata T, Asami N, Uragami T: Structural design of stimuli-responsivebioconjugated hydrogels that respond to a target antigen. Journal of Polymer Science part B Polymer Physics 2009; 47:2144?57.
  92. Miyata T, Asami N and Uragami T: Preparation of an antigen-sensitive hydrogel using antigen?antibody Macromolecules 1999; 32:2082?4.
  93. Miyata T, Asami N, Uragami T: A reversibly antigen-responsive Nature 1999; 399:766?9.
  94. Um SH, Lee JB, Park N, Kwon SY, Umbach CC, Luo D: Enzyme-catalysed assembly of DNA hydrogel. Nature Materials 2006;5:797?801.
  95. Xing YZ, Cheng EJ, Yang Y, Chen P, Zhang T, Sun YW, Yang ZQ and Liu DS. Self-assembled DNA hydrogels with designable thermal and enzymatic responsiveness. Advanced Materials 2011; 23:1117?21.
  96. Wei B, Cheng I, Luo KQ and Mi YL: Capture and release of protein by a reversible DNA-induced sol?gel transition system. Angewandte Chemie International Edition 2008; 47:331?3.
  97. Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future. Nature Reviews Drug Discovery 2004; 3:1023?35.
  98. Li J: Self-assembled supramolecular hydrogels based on polymer?cyclodextrin inclusion complexes for drug delivery. NPG Asia Materials 2010; 2:112?8.
  99. Kretschmann O, Choi SW, Miyauchi M, Tomatsu I, Harada A, RitterH: Switchable hydrogels obtained by supramolecular cross-linking of adamantyl-containing LCST copolymers with cyclodextrindimers. Angewandte Chemie International Edition 2006; 45:4361?4365.
  100. Van de Manakker F, van der Pot M, Vermonden T, van Nostrum CF and Hennink WE: Self-assembling hydrogels based on beta-cyclodextrin/cholesterol inclusion complexes. Macromolecules2008; 41:1766?1773.
  101. Lehn J-M: From molecular to supramolecular chemistry. In:Supramolecular chemistry. Weinheim: Wiley-VCH; 1?9.
  102. Bilensoy E, Rouf MA, Vural I, Sen M, Hincal AA: Mucoadhe?sive, thermosensitive, prolonged-release vaginal gel for clotrimazole:beta-cyclodextrin complex. AAPS PharmSciTech. 2006;7(2):E38.
  103. Dholakia M, Thakkar V,Patel N,Gandhi T: Development and characterisation of thermo reversible mucoadhesive moxifloxacin hydrochloride in situ ophthalmic gel, Journal of Pharmacy and Bio allied Science.2012; 4:S42?S45.
  104. Jung Y.S, Park W, Park H, Lee D.K, & Na K: Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127for sustained NSAID delivery. Carbohydrate Polymers2017; 156: 403?408.
  105. Yong C.S, Choi J.S., Quan Q.-Z, Rhee J.D, Kim C.K, Lim S.J, Kim K.M, Oh P.S., Choi S.G: Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. International Journal of Pharmaceutics 2001; 226 :195? 205.
  106. Hiemstra C., Zhong Z, Van Tomme SR,? van Steenbergen M.J,? Jacobs J.J,? Den Otter W, Hennink WE,? Feijen J : In vitro and in vivo protein delivery from in situ forming poly (ethylene glycol)?poly (lactide) hydrogels. Journal of Controlled Release 2007; 119:320?327.
  107. Jiang T, Sun C, Shen X, Wang T,Wang S : Development of a poloxamer analogs/bioadhesive polymers-based in situ gelling ophthalmic delivery system for tiopronin. Journal of Applied Polymer Science 2009; 114: 775?783.
  108. Xuan JJ, Balakrishnan P, Oh DH, Yeo WH, Park SM, Yong CS and Choi S.G. :Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam. International Journal of Pharmaceutics 2010; 395:317?23.
  109. Fu S, Ni P, Wang B, Chu B, Zheng L, Luo F & Qian Z : Injectable and thermo-sensitivePEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration. Biomaterials 2010 ;33: 4801?4809.
  110. Mandal B. B, Priya A S, & Kundu, S C: Novel silk sericin/gelatin 3-Dscaffolds and 2-D films: Fabrication and characterization for potential tissue engineering applications. Acta Biomaterialial 2009 ; 5: 3007?3020.
  111. Domingos M., Chiellini F, Cometa S, De Giglio E, Grillo-Fernandes E., & B?rtolo,P: Evaluation of in vitro degradation of PCL scaffolds fabricated via Bio Extrusion. Part 1: Influence of the degradation environment. Virtual and Physical Prototyping 2010; 5: 65?73.
  112. Fu A, Gwon K, Kim M, Tae G, & Kornfield, J A : Visible-light-initiated thiol?acrylate photopolymerization of heparin-based hydrogels. Biomacromolecules, 2015 ;16: 497?506.
  113. Siepmann J, Peppas N: Modeling of drug release from delivery systems based on hydroxypropylmethylcellulose (HPMC). Advanced Drug Delivery Reviews 2012; 64:163?74.
  114. Roughley, P, Hoemann, C., DesRosiers, E., Mwale, F., Antoniou, J, Alini, M : The potential of chitosan-based gels containing intervertebraldisc cells for nucleus pulposus supplementation. Biomaterials 2006; 27: 388?396.
  115. Nirmal, H.B, Bakliwal, S.R., Pawar, S.P: In-situ gel: new trends in controlled and sustained drug delivery system. International. Journal of Research 2010; 2: 1398?1408.
  116. Song J, Bi H, Xie X, Guo J, Wang X., Liu D.. Preparation and evaluation of sinomenine hydrochloride in situ gel for uveitis treatment. International Immunopharmacology 2013; 17: 99?107.
  117. Xiang NX, Zhou X, HeXY, ZhangY, ZhangJJ, ZhangZR: An injectable gel platform for the prolonged therapeutic ceffect of pitavastatin in the management of hyperlipidemia. Journal of pharmaceutical sciences 2016; 105:1148?55.
  118. Abashzadeh Sh , Dinarvand R, Sharifzadeh M ,? Hassanzadeh G ,? Amini M ,? Atyabi F: Formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelinacetate. European Journal of Pharmaceutical Sciences 2011 44: 514?521
  119. Goh1 M, Kim1 Y, Gwon K, Min K,? Hwang Y,Giyoong T: In situ formation of injectable and porous heparin-based hydrogel. Carbohydrate Polymers 2017; 174 : 990?998

Similar Articles

Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.