15Feb 2018

CLINICO-EPIDEMIOLOGICAL PROFILE OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN A HOSPITAL OF NORTH INDIA: A RETROSPECTIVE STUDY.

  • Associate Prof. Department of Pathology, Acharya Shri Chander College of Medical Sciences & Hospital.
  • Assistant Prof. Department of Microbiology, Acharya Shri Chander College of Medical Sciences & Hospital.
  • 1st year PG student, Department of Pathology, Acharya Shri Chander College of Medical Sciences & Hospital.
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Despite all the advances in the last century, tuberculosis (TB) is still a major problem of public health importance. It is one of the top 10 causes of death worldwide. Material and methods: A retrospective record based study on diagnosed cases of tuberculosis, both pulmonary and extra pulmonary was conducted in a tertiary care hospital of North India for a duration of two and a half years. The information about demographic profile, risk factors, clinical presentation and various diagnostic tests done were obtained from medical case records and analyzed. Results: The study included 230 TB patients. Of these, 82.6% had pulmonary TB and 17.4% had extra pulmonary TB. Male to female ratio was 1.7:1. The number of patients in the age group 20-40 years was greatest. Disseminated TB (30%), abdominal TB (22.5%) and lymphadenitis were the most common form of EPTB. Majority of the cases (74.7%) were from rural areas. History of contact was present in 13% cases. The percentage of smokers and alcoholics in our study was 38.2% and 16% respectively. Diabetes was present in 19.1% patients. Mantoux test was positive in 53% cases and 62.7% were smear positive on ZN staining. Conclusion: TB mostly affects the young and economically productive age group especially from rural areas. It is very important to educate the rural folks about the disease, its mode of spread and create appropriate health care facilities.


  1. World Health Organization (WHO), ?Global Tuberculosis Report 2016,? http://www.who.int/tb/publications/global_report/gtbr2016_main_text.pdf
  2. Babamahmoodi F, Alikhani A, Charati JY, Ghovvati A, Ahangarkani F, Delavarian L. Clinical Epidemiology and Paraclinical Findings in Tuberculosis Patients in North of Iran. BioMed Research International 2015; 2015, Article ID 381572, 5 pages. doi:10.1155/2015/381572
  3. Gupta S, Shenoy VP, Bairy I, Srinivasa H, Mukhopadhyay C. Diabetes mellitus and HIV as comorbidities? in tuberculosis patients of rural south India.J Infect Public? 2011; 4(3):140-4. doi:10.1016/j.jiph.2011.03.005.
  4. Swaminathan S and Narendran G. HIV and tuberculosis in India. Biosci. 2008; 33 527? 37.
  5. Khan QH. Epidemiology of pulmonary tuberculosis in rural Aligarh. Indian Journal of Community Medicine 2006;31: 39?40.
  6. Gupta S,?Shenoy VP,?Mukhopadhyay C,?Bairy I,?Muralidharan S. Role of risk factors and socio-economic status in pulmonary tuberculosis: a search for the root cause in patients in a tertiary care hospital, South India. Trop Med Int Health 2011;16(1):74-8. doi: 10.1111/j.1365-3156.2010.02676.x.
  7. L. Kasper, E. Braunwald, S.Hauser, D. Longo, J. L. Jameson,and A. S. Fauci, ?Tuberculosis,? in Harrison?s Principle of InternalMedicine, pp. 953?966,McGraw-Hill, New York, NY, USA, 17th edition, 2008.
  8. Khaliq A, Khan IH, Akhtar MW, Chaudhry MN. Environmental Risk Factors and Social Determinants of Pulmonary Tuberculosis in Pakistan. Epidemiology (sunnyvale) 2015; 5: 201. doi:10.4172/2161-1165.1000201
  9. Shetty N, Shemko M, Vaz M, D?souza G. An epidemiological evaluation of risk factors for tuberculosis in southIndia: a matched case control study. Int J Tuberc Lung Dis 2006; 10:80-6.
  10. Prakasha SR, Suresh G, D?sa IP, Shetty SS, Kumar SG. Mapping the Pattern and Trends of Extrapulmonary Tuberculosis. J Glob Infect Dis. 2013;5(2):54-9.doi: 10.4103/0974-777X.112277.
  11. Narain JP, Lo YR. Epidemiology of HIV-TB in Asia.Indian J Med Res. 2004; 120(4):277-89.
  12. Koul AN, Wagay HA, Rather AB, Dhobi GN, Bhat FA, Bhat MR. Demography and clinical outcome of pulmonary tuberculosis in Kashmir; 2 year prospective stud Egyptian Journal of Chest Diseases and Tuberculosis 2016; 65: 455?60.
  13. Wagay HA, Rather AB, Dhobi GN Koul AN. Demography, Clinico-Pathological Features and Outcome of Extrapulmonay Tuberculosis: 2 Years Prospective Study. Journal of Medical Science and clinical Research 2017; 5:17351-8.
  14. Shrivastava AK, Brahmachari S, Pathak P, Kumar Ratan, SainiaT, Patel U, Mandil A. Clinico-Epidemiological Profile of Extra-pulmonary Tuberculosis in Central India. Int J Med Res Rev 2015; 3(2):223-230. doi: 17511/ijmrr.2015.i2.046.
  15. Gaur PS, Suryakant, Bhaskar R, Singh S, Saxena P and Agnihotri S. Incidence and Clinical profiles of Pulmonary and Extra-Pulmonary Tuberculosis patients in North Indian population: A hospital based Retrospective study. J. Res. Dev. Pharm. L. Sci.2017; 6(5):2773-2778.doi: 10.13040/IJRDPL.2278-0238.6(5).
  16. Sreeramareddy CT, Ramakrishnareddy N, Shah RK, Baniya R, Swain PK. Clinico-epidemiological profile and diagnostic procedures of pediatric tuberculosis in a tertiary care hospital of western Nepal-a case-series analysis. BMC Pediatrics 2010; 10:57. doi:10.1186/1471-2431-10-57
  17. Mazta SR, Kumar A, Kumar P. Demographic Profile of Childhood TB cases under Revised National Tuberculosis Control Program in Himachal. NTI bulletin 2012; 48: 1-9.
  18. Acharya D, Majra JP. A clinical epidemiological study of tuberculosis among hospitalized cases in dakshina Kannada district of Karnataka. NTI bulletin 2007; 43: 43-6.
  19. Chennaveerappa PK, Siddharam SM, Halesha BR, Vittal BG, Jayashree N. Treatment outcome of tuberculosis patients registered at dots centre in a teaching hospital, South India. Int J Biol Med Res 2011; 2:487-9.
  20. Ayatollahi, M. R. Sharifi, H. Razmi, and B. Mahmoodiardekani,?The survey of tuberculosis patients in Yazd andShiraz,? Tolou?e Behdasht Yazd Research Journal 2010; 9(1): 35?40.
  21. Talay F & Kumbetli S. Risk factors affecting the development of tuberculosis infection and disease in household contacts of patients with pulmonary tuberculosis. Turkish Respiratory Journal 2008; 9:34?7.
  22. Lonnroth K, Williams BG, Stadlin S, Jaramitto E & Dye C. Alcohol use as a risk factor for tuberculosis ? a systematic review. BMC Public Health 2008; 8: 289.
  23. Burnet et al. High prevalence ofsmoking among patients with suspected tuberculosis in South Africa. EurRespir J 2011; 38: 139?46.
  24. Jeon CY & Murray MB (2008) Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies. PLOS Medicine 5, e152.

[Aneeta Singh Malhotra, Dipender Kaur Najotra and Sahil Sachdev. (2018); CLINICO-EPIDEMIOLOGICAL PROFILE OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN A HOSPITAL OF NORTH INDIA: A RETROSPECTIVE STUDY. Int. J. of Adv. Res. 6 (Feb). 616-621] (ISSN 2320-5407). www.journalijar.com


Dipender Kaur Najotra
Assistant Prof. Department of Microbiology, Acharya Shri Chander College of Medical Sciences & Hospital

DOI:


Article DOI: 10.21474/IJAR01/6479      
DOI URL: https://dx.doi.org/10.21474/IJAR01/6479