PRF and PRP in periodontal regeneration- A comparative clinical and radiological study

This randomized, longitudinal interventional study was carried out on 17 systemically healthy subjects to evaluate and compare, clinically and radiographically, the efficacy of a combination of Platelet-rich-Fibrin and Bioactive Glass, Platelet-rich-Plasma and Bioactive Glass and Bioactive Glass alone in the treatment of periodontal endosseous defects. Materials and methods 30 intrabony defects were selected and divided into three groups randomly by the coin toss method. Group I received bioactive glass (PerioGlas®) only. Group II subjects were treated with a combination of Platelet- rich Plasma and PerioGlas® and Group III, with a combination of Platelet- rich Fibrin and PerioGlas®. Clinical and radiological parameters were assessed at baseline and 3, 6 and 9 months postoperatively. The results obtained were statistically analyzed. Results The difference in Probing Pocket Depth (PPD) between the Groups I and III and Groups II and III were significant at the end of 9 months. The difference in Clinical Attachment Level (CAL) at the end of 9 months was significant between the Groups I and III and Groups II and III. The difference in depth of defect between the Groups I and II, Groups I and III were significant at the end of 9 months. Conclusion Platelet-rich Fibrin and Platelet-rich Plasma appear to have nearly comparable effects in terms of periodontal regeneration, with Platelet-rich Fibrin displaying slightly superior effect in comparison to Platelet-rich Plasma, which in turn displayed a superior efficacy in comparison to the bioactive glass synthetic bone graft particles alone. Clinical significance The results from the study indicate that Platelet-rich-Plasma (PRP), Platelet-rich-Fibrin (PRF) in combination with bioactive glass synthetic bone graft particles and bioactive glass synthetic bone graft particles alone are efficacious materials in the treatment of periodontal endosseous defects and can be used as effective regenerative materials.