AMELIORATING EFFECTS OF MARJORAM LEAVES EXTRACT AGAINST HEPATIC DISORDER IN MALE RATS.

  • Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
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The present study aims to evaluate the protective role of marjoram (M) leaves extract against hepatic disorder- induced by thioacetamide (TAA) in male rats. Male Wister rats (150-200 gm) were divided into eight groups (6 rats / each). Group 1 normal control. Groups 2 and 3 received 200mg and 400 mg/kg bw ethanolic extract of marjoram (M) leaves respectively. Group 4 received 100mg/kg of silymarin (Sly). Group 5 received 200mg/kg/ bw of TAA. Group 6 received M200 with TAA. Group 7 received M400 with TAA. Group 8 received Sly with TAA. All treatments continued for 8 weeks. The results showed that treatment with TAA caused decrease in the body weight and increase liver weight. Also, the results showed changes in the hepatic function biomarkers which characterized by increased activities of serum enzymes(ALT, AST, ALP, GGT) and total bilirubin associated with decrease in total protein and albumin contents. Also, increased serum levels of total lipid (TL), total cholesterol (TC), triglycerides (TG) and LDL-C with significant decrease in HDL-C. Moreover, the results showed significant decrease in hepatic TAC, SOD, GSH, GST and CAT activities while hepatic MDA level showed significant increase in TAA group. Treatment of animals with ethanolic extract of M in doses of 200 mg and 400 mg/ kg bw significantly reduced the TAA induced changes in the serum enzymes activities, lipid profile and antioxidants to near normal values. In conclusion, the results of the study indicated that the ethanolic extract of M has hepatoprotective activity against TAA induced hepatotoxicity in rats compared to Sly. The hepatoprotective effect of M may be due to the different antioxidant constituents that reduce oxidative stress and in hence the antioxidant status.

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[Wafaa M. El-Kholy, El-Sayed M.El-Habibi and Rehab El-Megrabi. (2018); AMELIORATING EFFECTS OF MARJORAM LEAVES EXTRACT AGAINST HEPATIC DISORDER IN MALE RATS. Int. J. of Adv. Res. 6 (May). 613-622] (ISSN 2320-5407). www.journalijar.com

Wafaa M. El-Kholy
Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

DOI:

Article DOI: 10.21474/IJAR01/7074      
DOI URL: https://dx.doi.org/10.21474/IJAR01/7074

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