Vol. 6 (05) pp. 1138-1144 DOI: 10.21474/IJAR01/7139

CORIANDRUM SATIVUM: A POTENTIAL SOURCE OF THERAPEUTIC COMPOUND AGAINST CARDIOVASCULAR DISEASES.

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  • Bacteriology Laboratory, Department of P. G. Studies and Research in Biological Science, Rani Durgavati University, Madhya Pradesh, India.
  • Department of Botany, Mata Gujri Women?s College, Jabalpur (M.P.) India.
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Abstract

Objectives: The increasingly high incidence of cardiac diseases caused by thrombosis of the arterial vessels is one of the major factors that threaten people?s health and lives around the world. Fibrinolytic agents are used to dissolve the clots in the blood vessels; however these agents have certain limitations. Herbal remedies, considered to be both safe and effective by most consumers. Coriandrum sativum has been documented as traditional treatment for cardiac diseases. Therefore, the present study was designed to investigate the effectiveness of C. sativum (Cor 32, Cor 75, Acr 2, RG 728, Cor 75) as a fibrinolytic agent for the treatment of cardiac diseases. Materials and method: The fibrinolytic activity of C. sativum varieties (Cor 32, Cor 75, Acr 2, RG 728, Cor 75) were qualitatively determined by plate and in vitro clot lysis assay. Preliminary Phytochemical analysis of flavanoids, tannins, alkaloids, saponins, resins, carbohydrates, steroids, terpenoids and glycosides were made by following standard protocol. Observation: The phytochemical analysis of the extract showed the presence of resins, glycosides, terpenoids, carbohydrates and flavanoids. The maximum fibrinolytic activity was showed by methanol extract of Cor 32 against the entire test compared with positive control (streptokinase and heparin) and negative control (distilled water). Thus, C. sativum of variety Cor 32 is suggested to have potential for pharmaceutical exploitation in the treatment of cardiovascular diseases.

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How to Cite This Article

Anjana Sharma, Shweta Golhani and Meenal Budholia Rehman. (2018); CORIANDRUM SATIVUM: A POTENTIAL SOURCE OF THERAPEUTIC COMPOUND AGAINST CARDIOVASCULAR DISEASES., International Journal of Advanced Research (IJAR), 6 (05), 1138-1144, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/7139

Corresponding Author

Anjana Sharma
Bacteriology Laboratory, Department of P. G. Studies and Research in Biological Science, Rani Durgavati University, Madhya Pradesh, India.

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References

  1. Astrup, T.S. and Mullertz, S. (1952): The Fibrin Plate Method for Estimating Fibrinolytic Activity. Arch. Biochem. Biophy., 40: 346-351.
  2. Bazzano, L.A., He, J., Ogden, L.G., Loria, C.M., Vupputuri S., Myers L. and Whelton, P.K. (2002): Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Am. J. Clin. Nutr., 76: 93-99.
  3. Harborne,?S.B.?(1984): A?Guide?to?Modern?Techniques?of?Plant?Analysis,?Chapman?and?Hall,?London.? p.?4.
  4. Khan, M.R. and Zehra, H. (2011): Amelioration of CCl (4)-induced nephrotoxicity by Oxalis corniculata in rat. Exp. Toxicol. Pathol., 65(3):327-34.
  5. Mahajan, P.M., Nayak, S. and Lele, S.S. (2012): Fibrinolytic enzyme from newly isolated marine Bacillus subtilis ICTF-1: media optimization, purification and characterization. J. Biosci. Bioeng., 113: 307-314.
  6. Mahendra, P., Bisht, S. (2011): Coriandrum sativum: A Daily se Spice with Great Medicinal Effect. Pharmacognosy J., 3(21): 84-88.
  7. Mandal, S., and Mandal, M. (2015): Coriander (Coriandrum sativum) essential oil: Chemistry and biological activity. Asian. Pac. J. Trop. Biomed., 5(6): 421?428.
  8. Nascimento, T.P., Sales, A.E., Porto, C.S., Brandao, R.M.P., Takaki, G.M.C., Teixeira, J.A.C., Porto, T.S. and. Porto, A.L.F. (2015): Production and Characterization of New Fibrinolytic Protease from Mucor subtillissimus UCP 1262 in Solid-State Fermentation. Advan. Enz. Res., 3: 81-91.
  9. Paulswamy, S. and Jeeshan, M.V. (2011): Preliminary phytochemistry and antimicrobial studies of an endangered medicinal herb Exacum biocolor Roxb. Res. J. Pharm. Biol. Chem. Sci., 2(4): 447-457.
  10. Prasad, S., Kashyap, R.S., Deopujari, J.Y., Purohit, H.J and Daginawala, H.F. (2007): Effect of Fagonia Arabica (Dhamasa) on in vitro thrombolysis, Complement. Altern. Med. 7(36) doi:10.1186/1472-6882-7-36
  11. Rahman, M.A., Sultana, R., Emran, T.B., Islam, M.S., Rahman, M.A., Chakma, J.S., Rashid, H. and Hasan, C.M.M. (2013): Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity. Complement. Altern. Med., 13:25.
  12. Shahwar, M.K., El-Ghorab, H., Anjum, F.M., Butt, M.S., Hussain, S., Nadeem, M. (2012): Characterization of coriander (Coriandrum sativum) seeds and leaves: volatile and non volatile extracts. Int. J. Food. Prop., 15: 736-47.
  13. Sharma, A. and Sharma, A. (2017): Screening of Citrobacter sp. for fibrinolytic protease production isolated from River Narmada. Inter. J. Adv. Res. Dev., 2(6): 721-725.
  14. Sharma, A., Patel, V.K., Rawat, S., Ramteke, P. and Verma, R. (2010): Identification of the antibacterial component of some Indian medicinal plants against Klebsiella pneumonia, J. Parma. Sci. 2 (3).
  15. Silva, G.M.M., Bezerra, R.P., Teixeira, J.A., Silva, F.O., Correia, J.M., Porto, T.S., Lima-Filho, J.L. and Porto, A.L.F. (2016): screening, production and biochemical characterization of a new fibrinolytic enzyme produced by Streptomyces Sp. (Streptomycetaceae) isolated from Amazonian Lichens. Acta. Amazonica., 46(3): 301 ? 310.
  16. Simkhada, J.R., Mander, P., Cho, S.S., Yoo, J.C. (2010): A novel fibrinolytic protease from Streptomyces sp. CS684. Proc Bioch. 45: 88-93.
  17. Sofowora,?E.A. (1993): Medicinal?and?traditional?medicine?in Africa.?(3rd?edn).?Spectrum?books?limited, Nigeria.?;?p.?9.
  18. Vasanthi, H.R. and Parameswari, R.P. (2010): Indian Spices for Healthy Heart - An Overview. Curr. Cardio. Rev., 6: 274-279.

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