Effect of CD –cholesterol on activity of ?-hemolysin production by Methicillin resistant Staphylococcus aureus (MRSA)

Methicillin – Resistant Staphylococcus aureus (MRSA) represent amajor problem in human medicine by causing both healthcare – associated and community associated infections .S.aureus secretes anumber of host injurious toxin, among the most prominent of which is the pore –forming toxin (?-hemolysin ) initially named based on its properties as a red blood cell lytic toxin . The present study focuses on the CD-cholesterol as achemical inhibitor of ?-toxin action .Some of bacterial infections are universally treated with antibiotics , which can eliminate the organism but cannot reverse the damage caused by bacterial products already presents .S.aureus produce proteins that directly or indirectly cause damage to the cell tissue that can result in reduced vision despite antibiotic treatment .CD-cholesterol is a good inhibitor of ?-toxin activity in vitro and we conscedered a good antivirulence agent might be useful in prophylaxis and as adjuvants in antibiotic therapy for MRSA infection.