Vol. 6 (09) pp. 587-592 DOI: 10.21474/IJAR01/7713

NEW INDICES FOR DIFFERENTIATION BETWEEN IRON DEFICIENCY ANEMIA AND BETA THALESSEMIA TRAIT, A STUDY IN CHILDREN.

  • Bsc.In haematology, Master of Science in haematopathology.
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Abstract

Background: The two most frequent types of microcytic hypochromic anemia in developing countries are beta thalassemia trait ( -TT) and iron deficiency anemia (IDA). Several indices using blood cell count parameters have been suggested to differentiate between two. Aim of study: In this study, we compared the ability of different three indices (Mentzer index, RDWI and MCI) to distinguish -TT from IDA by calculating their sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden?s index values. Methods: A total of 98 carefully selected children aged 1.0?17 years were evaluated. We calculated 3 discrimination indices in all patients with hemoglobin (Hb) values of 3.8?11.7 g/dL. None of the subjects had a combined case of IDA and -TT. The patient groups were evaluated according to red blood distribution width index; the Mentzer index and Matos and Carvalho index (MCI). Results: The Mentzer index was the most reliable index, as it had the highest sensitivity (96.06%), specificity (82.98%), and Youden?s index (79.04%) for detecting -TT; this was followed by the RDW index (87.23%, 86.27%, and 73.5%, resp.) and MCI (91.49%, 80.04%, and 71.53%). Conclusion: The Mentzer index provided the highest reliabilities for differentiating -TT from IDA.

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How to Cite This Article

MunaAbdulmueen Abdullah. (2018); NEW INDICES FOR DIFFERENTIATION BETWEEN IRON DEFICIENCY ANEMIA AND BETA THALESSEMIA TRAIT, A STUDY IN CHILDREN., International Journal of Advanced Research (IJAR), 6 (09), 587-592, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/7713

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Muna Abdulmueen Abdullah
Bsc. In haematology, Master of Science in haematopathology.

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