14Sep 2018

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CARICA PAPAYA AND FICUS BENGALENSIS LATEX ON THIOACETAMIDE INDUCED HEPATOTOXICITY IN RATS.

  • Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India.
  • Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India.
  • Department of Chemistry, Faculty of Pharmacy, Naraina Group of Institutions, Kanpur, U.P., India
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Study was designed to evaluate the hepatoprotective activity of Carica Papaya Latex at the dose 400mg/k.g. and Ficus Bengalensis Latex at the dose 300mg/k.g. per oral induced by thioacetamide at the dose 100mg/k.g. S.C..Hepatoprotective activity was observed by using bio-chemical parameters such as Serum-Glutamate Pyruvate Transaminase and Serum-Glutamate Oxalate Transaminase (SGPT and SGOT), total protein, Bilirubin, Alkaline Phosphate (ALP). Carica Papaya and Ficus Bengalensis Latex produced significant hepatoprotective effect by decreasing the activity of serum enzyme like SGPT, SGOT, Bilirubin, ALP, and elevated total protein level. Both plants latex were found completely prevented the toxic effect of thioacetamide on above serum parameters.

  1. Harsh Mohan, 5th Edition, Text book of Pathology, Jaypee brothers, Daryaganj, New Delhi, page no. 608-609.
  2. RajibAhsan, Km Monirul Islam (2009), Hepatoprotective activity of Methanol extract of some medicinal plants against Carbon Tetra Chloride induced hepatotoxicity in Albino rats, Global journal of Pharmacology, 3(3): pp. 116-122.
  3. MallikarjunaRaoTalluri, RajanandaswamyTadi (2016), Thioacetamide induced acute liver toxicity in rats treated with Balanitesroxburghii extracts, Journal of acute disease 5(5),pp. 413-418.
  4. Sharma A., K.K. Chakraborty and S.S. Handa (1991), Anti-hepatotoxic activity of some Indian herbal formulations as compared to Silymarin, Fitoterapia, 62: pp.229-235.
  5. Subramonium, A. and P. Pushpangadan (1999), Development of phytomedicines for liver disease. Indian Journal of Pharmacology, 31: pp. 166-175.
  6. Suk KT, Kim MY, Baik SK (2014), Alcoholic liver disease treatment, World J. Gastroenterol, 20(36) pp. 12934-44.
  7. Girish C. Pradhan, SC (2012),Indian herbal medicines in the treatment of Liver disease: problems and promises, FundamClin Pharmacology, 26(2), pp. 180-189.
  8. Wachtel ? Galor S., Benzie IFF (2011), Herbal medicine: Biomolecular and clinical aspects, 2nd Edition, Boca Raton: CRC Press.
  9. Phool Chandra, NeetuSachan (2013), Acute &Subchronic toxicity studies and Pharmacological evaluation of FicusBengalesis on scopolamine induced memory impairment in experimental animals, Indian Journal of drugs, 1(1),pp. 6-16.
  10. Mukherjee, P.K. Saha, K. Murugesan, T. Mandal (1998), screening of antidiarrhoeal properties of some plant extracts of a specific region of West Bengal, Indian Journal of Ethanopharmacology, 60,pp.85-89.
  11. Husain, A. Virmani, O.P. Popli, S. P. Mishra (1992), Dictionary of Indian Medicinal Plants CIMAP, Lucknow India.
  12. Achrekar,S. Kaklaji, G.S. Pote (1991), Hypoglycemic activity of Eugenia Jamolana and Ficus Bengalensis: Mechanism of Action. In VIVO, (5) pp. 143-147.
  13. Taur, D.J. Nirmal, S.A. Patil (2007), Anti-stress and Anti-allergic effects of Ficus Bengalensis bark in asthma. Natural Product Research., (21) pp. 1266-1270.
  14. Daniel RS,DeviKS,Augusti K.T.,(2003),Indian journal of experimental biology,41(4):pp.296-303.
  15. Shukla R., Anand K., Prabhu K.N. (1995), Indian journal Clin. Biochem., (10): pp. 14-18.
  16. A AAdeneye, JA Olagunju, (2009), Preliminary hypoglycemic and hypolipidamic activities of the aqueous seed extract of carica Papaya Linn in Wistar rats, Biology and Medicine, vol 1 (1), : 1-10.
  17. Duke JA (1984), Border Line Herbs. Boca Raton: CRC Press.
  18. Brocklehurst K, Salih E, McKee R., (1985), Fresh non-fruit latex of carica papaya contains papain, multiple form of chymopapain A and Papaya proteinase omega, Biochemical Journal, 228(2): pp.525-527.
  19. Tona L, kambu K, Ngimbi N. (1998), Antimoebic medicinal plants, Journal of Ethanopharmacology, 61(1), pp. 57-65.
  20. Odula T, Adeniyi (2007), Toxicity studies on an unripe Carica Papaya aqueous extract: Biochemical and haematological effects in Wister Albino rats, Journal of Medicinal plants research Vol.1 (1), pp. 001-004.
  21. ZaforSadeque and ZinnatAra Begum (2010), Protective effect of dried fruits of Carica Papaya on Hepatotoxicity in rats, A Journal of Bangladesh Pharmacological Society,( 5) : 48-50.
  22. ShilaGurung, Natasha Skalko- Basnet (2009), Wound healing properties of Carica Papaya Latex: In vivo evaluation in mce burn model, Journal of Ethanopharmacology, 121, pp. 338-341.
  23. Yogesh C Yadav, (2015), Hepatoprotective effect of Ficusreligiosa latex on cisplatin induced liver injury in Wister rats, RevistaBrasileira De Farmacognosia, pp. 278-283.
  24. Trease,?E.and?Evans,?W.C.?(1989), Pharmacognosy.?11th Edition,?BailliereTindall,?London, 45-50.
  25. PremaVeeraraghavan, Expert consultant, CPCSEA, OECD guideline Nol. 420.
  26. Anbarasu C, Rajkapoor B, John Giridharan (2012), Protective effect of Pisonia aculeate on thioacetamide induced hepatotoxicity in rats, Asian Pacific Journal of Tropical Biomedicine, 2(7): pp. 511-515.

[Yogendra kumar, Girendra Gautam and Pushpesh Kumar Mishra. (2018); EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CARICA PAPAYA AND FICUS BENGALENSIS LATEX ON THIOACETAMIDE INDUCED HEPATOTOXICITY IN RATS. Int. J. of Adv. Res. 6 (Sep). 294-299] (ISSN 2320-5407). www.journalijar.com

Yogendra Kumar
Research Scholar, Faculty of Pharmacy, Bhagwant University, Sikar Road, Ajmer, Rajasthan, India

DOI:

Article DOI: 10.21474/IJAR01/7674      
DOI URL: https://dx.doi.org/10.21474/IJAR01/7674

Download Full Paper

Download PDF No. of Downloads: 54 | No. of Views: 200