17Sep 2018

THE HYPOTHETICAL ROLE OF ZINC, MAGNESIUM, SELENIUM AND CAROTENOIDS IN THE PREVENTION OF PROSTATE CANCER: A Clinical basic study

  • Ministry of Science and Technology, Treatment and disposal of chemical, biological and, military hazardous wastes, Center for research and evaluation, Baghdad ? Iraq.
Crossref Cited-by Linking logo

Plum Print visual indicator of research metrics
  • Captures
    • Readers: 1
see details

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

This study aimed to estimate an essential traces elements levels of Zinc (Zn), Magnesium (Mg), and Selenium (Se) also β-carotene and Lycopene from carotenoids to evaluate their roles in protecting of prostate gland cells from various oxidative processes in order to protect DNA from mutation which results in the accidence of prostate cancer. the samples of the study are selected from the community were they suffering from prostate cancer were taken randomly from 15 of men, suffering from prostate and 13persons healthy men, aged 45 to 70 years old. Results showed a highly significant which decreased when p < 0.001 in all level of Zn, Mg, Se β-carotene, Lycopene

  1. Jamal, A., Siegel R., Ward E., Hao Y., Xu J., Thun, M.J.,m 2009. Cancer statistics, CA Cancer J. Clin. 59, 225-249
  2. Zaichick, V., Sviridova, T.V., Zaichick, S.V., 1997. Zinc in the human prostate gland: normal, hyperplastic and cancerous. IntUrolNephrol, 29, 565-74
  3. Iseri, LT., French, J.H. 1984. Magnesium: natures' physiologic calcium blocker. Am Heart. J 108, 188-193
  4. De Marzo, A.M., Platz, E.A., Sutcliffe, S., Xu, J., Gronberg, H., Darke, C.G., Nakai, Y., Isaacs, W.B., Nelson.W.G., 2007. Inflammation in prostate carcinogenesis. Nat Rev Cancer. 7, 256-269
  5. Combs, G.F., 2004. Status of selenium in prostate cancer prevention. Br. J. Cancer. 91, 195-199
  6. Dong, Y., Lee, S.O., Zhang, H., Marshall, J., Gao A.C., Ip, C. 2004. Prostate-specific antigen expression is down-regulated by selenium through disruption of androgen receptor signalling.Cancer Res. 64, 19?22
  7. Driscoll D.M. Copeland, P.R. 2003. Mechanism and regulation of selenoprotein synthesis.Annu Rev Nutr?23, 17?40
  8. Jiang, C., Wang, Z., Ganther, H., Lu, J. 2001. Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.Cancer Res. 61:3062?70
  9. Menter, D.G., Sabichi, A.L., Lippman, S.M., Selenium effects on prostate cell growth.Cancer Epidemiol Biomarkers Prev.9, 1171?1182
  10. Venkateswaran, V., Klotz, L.H., Fleshner, N.E., 2002. Selenium modulation of cell proliferation and cell cycle biomarkers in human prostate carcinoma cell lines.Cancer Res. 62:2540?2545
  11. Zhong, W., Oberley, T.D., 2001. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line.Cancer Res. 61:7071?7078
  12. Dong, Y., Zhang, H., Hawthorn, L., Ganther, H.E., Ip, C., 2003. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array.Cancer Res. 63, 52?59
  13. Rao, A.V. Agarwal, S., 1999. Role of lycopene as antioxidant-carotenoid in the prevention of chronic disease: a review. Nutr Res. 19, 305-323
  14. Kryukov, G.V, Castellano, S., Novoselov, S.V., Lobanov, A.V., Zehtab, O., Guig?, R., Gladyshev, V.N., 2003. Characterization of mammalian selenoproteomes.?Science. PubMed. 300:1439?1443
  15. George, A.F., 1981. Statistical Analysis in Psychology and Education, 5th McGraw- Hill Book Company.
  16. Peto, R., Doll, R., Buckley, J.D., Sporn, M.B., 1981. Can Dietary beta-carotene Materially Reduce Human Cancer Rates? Nature; 290, 201-208
  17. Wang, X.D., Russell, R.M., 1999. Procarcinogenic and anticarcinogenic effects of beta-carotene. Nutr. Rev. 57, 263-272
  18. Goel, T., Sankkhwar, S.N., 2006. Comparative study of zinc levels in benign and malignant lesions of the prostate. Scand J UrolNephrol. 40, 108-112
  19. Vartsky,D., Shilstein, S., Bercovich, A., Huszar, , Breskin, A., Chechik, R., KorotinskyS., S.D., Malnick,M.E., 2003.Prostaticzincandprostate-specificantigen:An experimentalevaluationoftheircombineddiagnosticvalue.J.Urol, 170, 2258-2262
  20. Wolf, F.I., Maier, J.A.M., Nasulewicz, A., Feillet-Coudray, M., Simonacci, C., Mazur, A. Cittadini, A., 2007. Magnesium and neoplasia: From carcinogenesis to tumour growth and progression or treatment. Arch BiochemBiophys. 458, 24-32
  21. Castiglioni, S., Maier, J.A.M., 2011. Magnesium and cancer: a dangerous liaison. Magnes Res 24, S92-S100
  22. Anastassopoulou, J., Theophanides, T., 2002. Magnesium- DNA interactions and the possible relation of magnesium to carcinogenesis. Irradiation and free radicals. Crit Rev OncolHematol. 42, 79-91
  23. Dent, G.M., Zwahlen, M., Brinkman, M., Vinceti, M., Zeegers, M.P., Horneber, M., 2011. Selenium for preventing cancer. Cochrane Database SystRen: 11: (5):CD005195.
  24. Renty, B.F. Leslie, C.C., 2007. Zinc as antitumour agent in prostate cancer and in other cancers. 463, 211-217
  25. Rao, A.V., Fleshner N., Agarwal, S. 1999. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control Nutr cancer 33, 159-16.

[Saeed Hussein Assi and Ahmed Ibrahim Jessim (2018); THE HYPOTHETICAL ROLE OF ZINC, MAGNESIUM, SELENIUM AND CAROTENOIDS IN THE PREVENTION OF PROSTATE CANCER: A Clinical basic study Int. J. of Adv. Res. 6 (Sep). 457-463] (ISSN 2320-5407). www.journalijar.com

Ahmed Ibrahim Jessim
Scientific researcher in Ministry of science and technology

DOI:

Article DOI: 10.21474/IJAR01/7696      
DOI URL: https://dx.doi.org/10.21474/IJAR01/7696

Download Full Paper

Download PDF No. of Downloads: 9 | No. of Views: 54