03Dec 2018


  • laboratory of pharmacodynamics and experimental physiopathology (l2pe) of the faculty of science and technology, marien university ngouabi.
  • laboratory of biochemistry and pharmacology, faculty of health sciences, marien university ngouabi.
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This work aims to evaluate the antidiabetic and wounds healing activities of the leaves extract of Ecliptaprostrata. Antidiabetic activity was evaluated respectively in normal and hyperglycemic rats by overdose of glucose 10% at 3g/kg orally and, in the rat made diabetic of type II by intravenous injection of the streptozotocine 45mg/kg. The wound healing activity was evaluated by incision of approximately 1cm2 on the beforehand shaven back of rat.The obtained results revealed that the aqueous extract (200, 400 and 800 mg/kg) descrease significantly the peak of glycemia compared to the obtained with distilled water in the rats, 30 min after the overdose of glucose. This decrease continues until the 5th hour and, the extract effect occurs at different hours according to the doses. In the same way, the ointment A and B, respectively with aqueous and hydro-ethanolic extract added with vaselin, significantly reduce the wounds diameters. The wounds were completely healed after 14 day by the ointment against 18 day for vaselin and cicatryl. These results justify the use of E. prostratain traditional medicine against diabetes and wounds.

  1. Hajzadeh, M., Rajaci, Z., Ghamami, G., Tamiz, A. (2011). The effect of Salvia officinalis leaf Extract on Blood Glucose in Streptozocin-Diabetics. Pharmacology Online, 1, 213-220.
  2. Sambo, M.H. (2011). Diabetes Atlas, 5th edition. International Diabetes Federation, 36.
  3. Diabaction Congo Association, (2015). Epidemiology of Diabetes in Congo Brazzaville. Africa news, 10.
  4. Grimaldi, A., Cornet, P., Masse-Boeuf, N., Popetier, M., Sachon, C. (1997). Guide Practice of diabetes. Editions Mimi, Paris, 136.
  5. Nissen, S.E., Wolski, K. (2007). Effect of Rosiglitazone on the risk of mycardial infarction dearth from cardiovascular causes.New England Journal of Medicine, 356, 2457-2471.
  6. Nissen, S.E. (2010). Setting the record straits. Journal of the American Medical Association, 303,?1194-1195.
  7. WHO, 2008. Diabetes. Media Center. Memorandum No. 312.
  8. Dithala, S., Kiranmai, M., Dorababu, N., Mohammed, I. (2012). Pharmacognostical, phytochemical and analgesic activity of ecliptaprostrata. l (Asteraceae). Journal of Global Trends in Pharmaceutical Sciences, 3, (3), 740-746.
  9. Mohamed, S.G.A and Nalini D. (2015). Activity of Methanolic extract of Ecliptaprostrata (L.) L. International Journal of Phytopharmacy, 5, (2): 21-24.
  10. Tewtrakul, S., Subhadhirasakul, S., Tansakul, P., Cheenpracha, S. (2011). Antiinflammatory constituents from Ecliptaprostrata using. RAW264.7. Macrophage cells. Phytotherapy Research. 25,(9): 1313-6.
  11. Ahombo, G., Ampa, R., Diatewa, M., Abena, A.A., Ouamba, J.M. (2012). Investigation on related diabetic seedlings used in traditional medicine at Brazzaville. Journal of Medical Plants Research, 6,(44), 5630-5639.
  1. Tedong, L., Dzeufiet-Djomeni, D.P., Dimo, ​​T., Asongalem, A.E., Sokeng, S.N., Flejou, F.J., Callard, P., Kamtchouing, P. (2007). Effect of hexane extract of?leaves of western Anacardium (Anacardiaceae) on the function of?reproduction in rats made diabetic by streptozotocin. Phytotherapy, 5, 182-193.
  2. Klotoe, J.R., Dougnon, T.V., Dougnon, T.J., Agbodjento, E., Ategbo, J.M. and Loko, F. (2014). Jatrophamultifida Linn (Euphorbiaceae): Exploration properties
  3. Ampa, R., Ahombo, G., Nguimbi, E., Diatewa, M., Dimo, ​​T., Ouamba, M.J., Abena, A.A. (2013). Evaluation of hypoglycemic, antihyperglycemic and antidiabetic properties of TriplesiummadagascariensesC. Leuwenberg (Moraceae). E3 Journal of?Biotechnology and Pharmaceutical Research, 4, (3), 48-53.
  4. Ndomou, M., Djidjou, K.P., Ayong, N.H., Gouado, I., Tchregang, C. (2014). Activity evaluation antidiabetic agents of the leaves of Gnetumafricanum and Gnetumbulchozzianum (Gneceae) 15, 60-65.
  5. Ampa, R., Morabandza, C.J., Okoumou, G.M.S., Diatewa, M. Ongoka, P. R. and Abena, A.A. (2018).Antidiabetic activity and chemical screening of the aqueous extract of seeds of strychnoscamptoneuragilg&busse (loganiaceae). World Journal of Pharmaceutical Research,7, (18), 322-332.
  6. Sissoko, F.K. (2012). Study of the phytochemistry and biological activities of Musa acuminata, Mangifera index, Boerha via erecta and Ecliptaprostrata. These pharmacy, 138.
  7. Ampa, R., Morabandza, C.J., Ahombo, G., Nguimbi, E., Diatewa, M., Abena, A.A., Dimo, T., Ouamba, J.M. (2017). Prevention of diabete complications by hydro-ethanolic extract of the leaves of trilepisiummadagascarienseLeeuwenberg D.C. (Moraceae). World journal of pharmacy and pharmaceutical sciences, 6, (11), 855-866.
  8. Bensegueni, A. (2007). Traditional ointments in the treatment of wounds and burns. State Thesis in Veterinary Science. Mebtouri University. Constantine, 21-22.
  9. Korotimi, D.A.K. (2010). Healing properties of the leaves of Opitiaceltidifolia (Guill and Perr) Endl. Ex Walp (Opiliaceae). Pharmacy thesis. University of Bamako. Faculty of Medicine Pharmacy and Odonto Stomatology, 109.

[Ampa Raoul, Morabandza Cyr Jonas, Samba Matoko Christevy Rommelle, Elion Itou De Garde Romaric, Diatewa Martin and Abena Ange Antoine. (2018); ANTIDIABETIC AND WOUNDS HEALING ACTIVITIES OF ECLIPTA PROSTRATA (ASTERACEAE) LEAVES. Int. J. of Adv. Res. 6 (Dec). 393-398] (ISSN 2320-5407). www.journalijar.com

Ampa Raoul
Laboratory of Pharmacodynamics and Experimental Physiopathology (L2PE) of the Faculty of Science and Technology, Marien University NGOUABI.


Article DOI: 10.21474/IJAR01/8151      
DOI URL: http://dx.doi.org/10.21474/IJAR01/8151