Hypoglycemic Effect Of Zingiber officinale On Hepatocytes Of Alloxan Induced Charls foster Rats

Background: Diabetes is a chronic metabolic disease, characterized by elevated blood glucose level. Diabetes in adults is more increasing in developing country. Ginger is the richest source of antioxidants having free radicals scavenging properties due to its component gingerols. The present study is designed to study hypoglycemic effect of Zingiber officinale on hepatocyte of diabetic Charls foster rats. Methods: Aqueous rhizome extract of Zingiber officinale (200 mg/kg/b.w/day) is administered orally to diabetic group of rat for eight weeks. Serum was collected for biochemical assay and liver tissues were collected for hepatocyte study. Results: It causes decrease in glucose up to normal level. Ginger restores SGPT and Lipid peroxidation effectively. Urea, Uric acid and creatinine were also restored effectively on administration of Zingiber officinal. The restoration was increased with increased duration of exposure. Ginger causes marked restoration in hepatic cells and central veins. It maintains both cytoplasm and chromatin material of hepatic cells of diabetic rat. Cytoplasm is restored more effectively in comparison to nucleus. Conclusion: Zingiber officinal plays active role in protection of hepatic cell of diabetic rats and maintains its normal integrity.