RECURRENT LARYNGEAL NERVE AND PARATHYROID GLAND SAVING BY SPRAYING METHYLENE BLUE DURING THYROIDECTOMY.
- General Surgery Departments, Faculty of Medecine, Zagazig University.
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Background:Visualization and saving of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs) are the most important two points during thyroid surgery. The aim of the study is evatulation of the use of intra operative methylene blue spraying during thyroidectomy in saving RLN and PGs. Patient and methods: Our study was done in general surgery department of Zagazig University hospital from March 2017 to September 2018 and follow up for about 6 months, included (53) patients with different types of goiter operated by total thyroidectomy with intra operative methylene blue spraying. Patients with recurrent thyroid surgery, preoperative vocal cords paresis, or retrosternal goiter were excluded. The patients underwent complete history taking, clinical examination, laboratory investigations including serum calcium level,TSH,freeT3,T4, neck US, C.T neck in some cases and indirect laryngoscopy pre and post operatively to assess the vocal cords mobility pre-and postoperatively. Informed consent was taken from all patients. Results: the study involved (53) cases, 43 females (81.1%) and 10 males (18.9%); age ranged from 27 to 61 years (mean: 41,5 year),the patients had; 35 (66.04%) simple nodular goiters, 9(16.98%) solitary thyroid adenoma,5 (9.43%) papillary thyroid carcinoma and 4 (7.55%) Graves? disease. Patients mean dischargedwere 1.6 days (1?4 days) with no cases of wound complications or operative mortality. 4 cases (7.55%) suffered from transient hypocalcaemia, for a maximum of four days. the RLN can be visualized in 47 cases (88.7%) after spraying the MB firstly but in the remaining six cases(11.3%) the RLN was present in deeper level and need more dissection until it is detected and saved. No cases were encountered of RLN injury with vocal cords paralysis or hypoparathyroidism
- Bron, L.P., O′Brien, C.J., 2004. Total thyroidectomy for clinically benign disease of the thyroid gland. Br. J. Surg.,91(5):569-574. [doi:10.1002/bjs.4507]
- Rosato, L., Avenia, N., Bernante, P., De Palma, M., Gulino, G.,Nasi, P.G., Pelizzo, M.R., Pezzullo, L., 2004. Complicationsof thyroid surgery: analysis of a multicentric study on 14934 patients operated on in Italy over 5 years. World J. Surg., 28(3):271-276. [doi:10.1007/s00268-003-6903-1]
- Hundahl SA, Fleming ID, Fremgen AM, et al. A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the US, 1985-1995. Cancer 1998; 83:2638-2648.
- Suh YJ, Choi JY, Chai YJ, et al. Indocyanine green as a near-infrared fluorescent agent for identifying parathyroid glands during thyroid surgery in dogs. SurgEndosc 2015; 29:2811-2817.
- D.&Woolf A.L. (1959) The Innervations of Muscles: A Biopsy Study. Blackwell, Oxford
- Wille-Jorgensen P. & Jensen H.E. (1981) Leucomethylene blue staining during vagotomy. Br. J. Surg. 68, 81?82.
- Nahlieli O. & Levy Y. (2001) Intravital staining with methylene blue as an aid to facial nerve identification in parotid gland surgery. J. Oral Maxillofac. Surg. 59, 355?356.
- Yazicia I., Kasimcanb M.O., Karakayaa E.I. et al. (2011) Methylene blue vital staining of nerve stumps in secondary peripheral nerve repair; Letter to the Editor.. Injury 42, 1387?1391.
- Seif C., Martınez Portillo F.J., Osmonov D.K. et al. (2004) Methylene blue staining for nerve-sparing operative procedures: an animal model. Urology 63, 1205?1208.
- Wagner, H.E., Seiler, C., 1994. Recurrent laryngeal nerve injury after thyroid gland surgery. Br. J. Surg., 81(2):226-228. [doi:10.1002/bjs.1800810222]
- Sturniolo, G., D′Alia, C., Tonante, A., Gagliano, E., Taranto,F., Lo Schiavo, M.G., 1999. The recurrent laryngealnerve related to thyroid surgery. Am. J. Surg., 177(6):485-488. [doi:10.1016/S0002-9610(99)00101-4].
- Lee NJ, Blakey JD, Bhuta S, et al. Unintentionalparathyroidectomy during thyroidectomy. Laryngoscope1999;109:1238-1240.
- Sasson AR, PingpankJr JF, Wetherington RW, et al. Incidental parathyroidectomy during thyroid surgerydoes not cause transient symptomatic hypocalcemia.ArchOtolaryngol Head Neck Surg 2001;127:304-308.
- Hisham, A.N., Lukman, M.R., 2002. Recurrentlaryngeal nerve in thyroid surgery: a critical appraisal.ANZ J. Surg72(12):887-889. [doi:10.1046/j.1445-2197.2002.02578.x].
- Rios-Zambudio A, Rodr0ıguez J, Riquelme J, Soria T, Canteras M, Parrilla P:Prospective study of postoperative complications after total thyroidectomy for multinodular goiters by surgeons with experience in endocrine surgery. Ann Surg 2004, 240:18?25.
- Bergenfelz A, Jansson S, Kristoffersson A, et al: Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients. Langenbeck Arch Surg 2008, 393:667?673.
- Ardito, G., Revelli, L., D′Alatri, L., Lerro, V., Guidi, M.L.,Ardito, F., 2004. Revisited anatomy of the recurrent laryngeal nerves. Am. J. Surg., 187(2):249-253.
- Bergamaschi, R., Becouarn, G., Ronceray, J., 1998. Morbidity of thyroid surgery. Am. J. Surg., 176(1):71-75.
- Thomusch, O., Sekulla, C., Dralle, H., 2003. Is primary total thyroidectomy justified in benign multinodular goiter? Results of a prospective quality assurance study of 45 hospitals offering different levels of care. Der Chirurg, 74(5):437-443 (In German).
- Mattig, H., Bildat, D., Metzger, B., 1998. Reducing the rate of recurrent nerve paralysis by routine exposure of the nerves in thyroid gland operations. Zentralbl. Chir.,123(1):17-20.
- Erbil Y, Barbaros U, Issever H, et al: Predictive factors for recurrent laryngeal nerve palsy and hypo parathyroidism after thyroid surgery. ClinOtolaryngol 2007, 32:32?37.
- Smith E, Verdolini K, Gray S, Nichols S, Lemke J, Barkmeier J: Effect of voice disorders on quality of life. J Med Speech-Language Pathol 1996, 4:223?244.
- Fang TJ, Li HY, Gliklich RE, Chen YH, Wang PC, Chuang HF: Quality of life measures and predictors for adults with unilateral vocal cord paralysis. Laryngoscope 2008, 118(10):1837?1841.
- Dralle H, Sekulla C, Haerting J, et al: Risk factors of paralysis and functional outcome after recurrent laryngeal nerve monitoring in thyroid surgery. Surgery 2004, 136:1310?1322.
- Falk SA, Birken EA, Baran DT: Temporary post thyroidectomy hypocalcemia. Arch Otolaryngol Head Neck Surg 1998, 114:168?174.
- Reeve T, Thompson NW (2000) Complications of thyroid surgery: how to avoid them, how to manage them, and observations of their possible effect on the whole patient.World J Surg 24:971?975.
- Ozbas S, et al (2005) Comparison of the complicationsof subtotal, near total and total thyroidectomy in thesurgical management of multinodulargoitre. Endocr J52:199?205.
- McHenry CR, et al (1994) Risk factors for post thyroidectomy hypocalcemia. Surgery 116:641?648.
- Sari, S., Aysan, E., Muslumanoglu, M., Ersoy, Y. E., Bektasoglu, H., &Yardimci, E. (2012). Safe thyroidectomy with intraoperative methylene blue spraying. Thyroid research, 5(1), 15.
[Hany Mohamed, Ashraf Goda and Hatem Mohammed. (2019); RECURRENT LARYNGEAL NERVE AND PARATHYROID GLAND SAVING BY SPRAYING METHYLENE BLUE DURING THYROIDECTOMY. Int. J. of Adv. Res. 7 (Feb). 651-656] (ISSN 2320-5407). www.journalijar.com