01Apr 2019

THROMBIN ENHANCES OVALBUMIN-SPECIFIC IGA IN MUCOSAL SURFACES BY INTRANASAL ADMINISTRATION IN MICE.

  • Development department, kikuchi research center, km biologics co., ltd., 1314-1 kyokushikawabe, kikuchi-city, kumamoto 869-1298, japan.
  • Department of medical technology, kumamoto health science university, 325 izumi-machi, kita-ku, kumamoto-city, kumamoto 861-5598, japan.
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Thrombin plays a central role in blood coagulation. In addition, thrombin is an important inflammatory mediator that activates T lymphocytes and monocytes and induces the release of proinflammatory cytokines in vitro. However, it has not been clarified whether thrombin can inducethe production ofantibodies against antigens in vivo; i.e., it is not known whether thrombin has an adjuvant effect to enhance immune responses. In the present study in mice, intranasally administered thrombin plus ovalbumin enhanced not only antigen-specificIgG in blood but also antigen-specificIgA on mucosa in the nasal cavity and intestine. IgA plays a major role in protecting against infection by preventing pathogens from invading the body through mucous membranes. This study provides new information regarding thrombin as an adjuvant of mucosal immunity.

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[Kazuyoshi Kaminaka and Chikateru Nozaki. (2019); THROMBIN ENHANCES OVALBUMIN-SPECIFIC IGA IN MUCOSAL SURFACES BY INTRANASAL ADMINISTRATION IN MICE. Int. J. of Adv. Res. 7 (Apr). 1-6] (ISSN 2320-5407). www.journalijar.com

Kazuyoshi Kaminaka
KM Biologics Co., Ltd

DOI:

Article DOI: 10.21474/IJAR01/8781      
DOI URL: https://dx.doi.org/10.21474/IJAR01/8781

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