Vol. 7 (04) pp. 1254-1258 DOI: 10.21474/IJAR01/8948

EFFECT OF KARELA ON THE PHARMACODYNAMICS OF PIOGLITAZONE IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS.

, and
  • Clinwave Research Private Limited, Kukatpally, Hyderabad.
  • A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam.
12 Downloads 72 Views
Crossref

Download Full Paper (PDF)

Abstract

Karela is a common name of Momordicacharantia. The present study was carried out to study the herb drug interactions between the traditional medicine Karela with Thiazolindinediones, Pioglitazone in normal and diabetic conditions. Blood samples were collected from rats by retro orbital puncture at regular intervals of time 0, 1, 2, 3, 4, 6, 8, 10, 12 hr of rats treated with Pioglitazone 5, 10 and 20mg/kg bd.wt and Momordicacharantia100 and 200mg/kg bd.wt. The Pioglitazone and Karelashoweddose dependent reduction of blood glucose levels. The optimum blood glucose reduction was obtained at 10mg/kg of pioglitazone and 200mg/kg of Karela in normal rats. The blood glucose levels were found to be decreased with corresponding elevated insulin levels in both single and multiple dose combinations of Pioglitazone and Karela in normal rats (4hr) as well as in alloxan induced diabetic rats (4hr) compared with the pioglitazone alone. Since the combination of Karela and pioglitazone produced severe hypoglycemia in combined treatment due to pharmacodynamic interactions, care must be taken while prescribing the combination in clinical situation.

Keywords

Article Analytics

References

  1. Shaheena M, Jan Barnsley, and?Raisa B. Deber. Accountability and primary healthcare. Healthc Policy. 2014; 10(SP): 90?98.
  2. Sandhya W. Global health care challenge: Indian experiences and newprescriptions. E J Biotech, 2004; 7: 217-223.
  3. Berman AF. Herb-drug interactions, The Lancet. 2000;355:134-8.
  4. Anthony, J.B., and C.M. Gregory. Pharmacology Weekly. Retrieved June 2014, from http://www.pharmacologyweekly.com/content/pages/cytochrome-cyp-p450-enzyme medication herbs- substrates.
  5. Deng LJ, Wang F, Li HD. Effect of gemfibrozil on the pharmacokinetics of pioglitazone. Eur J ClinPharmacol, 2005; 61: 831-836
  6. Bharathi K, Sandhya M and?KVSRG Prasad. Effect of?Moringaoleiferaon the Pharmacokinetics and Pharmacodynamics of Pioglitazone, The FASEB Journal, 2017;31(1): 822.5
  7. Trinder P, Determination of blood glucose using an oxidaase-peroxidase system with a non carcinogenicchemogen. J ClinPathol., 1961; 22: 158-161.
  8. Kala MJ, Tresina PS, Mohan VR. Antioxidant, antihyperlipidaemic and antidiabetic activity of?Eugenia floccosabedd leaves in alloxan induced diabetic rats.?J Basic Clin Pharm.?2012;3:235?40.
  9. Kliber A, Szkudelski T, Chichlowska J. Alloxan stimulation and subsequent inhibition of insulin release from in situ perfused rat pancreas. J PhysiolPharmacol 1996;47:321-8
  10. Pranja AS, Philip Eckand? Pratibha V Nerurkar. Modulation of Human Cytochrome P450 by Momordicacharantia (Bitter Melon). The FASEB Journal, 2009; 23(1): 5.
  11. Simone B, Mario S and Rupika D. Cytochrome P450 Enzyme Inhibitors from Nature, Enzyme Inhibition and Bioapplications, Prof. Rakesh Sharma (Ed.),2012; ISBN: 978-953-51-0585-5
  12. Lal VK, Gupta PP, Tripathi P, Pandey A. Iteraction of Momordicacharatia fruit juice with glibeclamide in streptozotocin induced diabetic rats. Pharmacologyonline, 2011; 3: 853-857.
  13. Tripathi P, Gupta PP and Vijay Kumar. Interaction of Momordicacharantiawith Metformin in Diabetic Rats, American Journal of Pharmacology and Toxicology, 2013, 8 (3): 102-106
  14. Nivitabishekam SN,?Asad M, Prasad VS. Pharmacodynamic interaction of Momordicacharantia with rosiglitazone in rats.ChemBiol Interact.2009 12;177(3):247-53.

How to Cite This Article

Rajasekhara Reddy T, Swathi P and Eswar Kumar K. (2019); EFFECT OF KARELA ON THE PHARMACODYNAMICS OF PIOGLITAZONE IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS., Int. J. of Adv. Res., 7 (04), 1254-1258, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/8948

Corresponding Author

Rajasekhara Reddy T.
Clinwave Research Private Limited, Kukatpally, Hyderabad.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.