Vol. 7 (05) pp. 1201-1206 DOI: 10.21474/IJAR01/9152

ADULT AND PEDIATRIC MULTIPLE SCLEROSIS: DIFFERENCES AND SIMILARITIES.

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  • Mansoura neurology department , Egypt.
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Abstract

Background: Multiple sclerosis (MS) can occur in pediatric age group with prevalence rates ranging from 2.2%-4.4% of all MS cases. This research conducted to compare adult multiple sclerosis with pediatric multiple sclerosis clinically and radiologically and to assess similarities and differences between them. Methods: 30 MS patients divided into 2 groups (Group A aged 18 years or more at first presentation, group B less than 18 years) underwent detailed history taking, general , neurological examination, MRI brain for location and number of lesions and disability assessment using Expanded Disability Status Scale. Results: No significant difference between the two groups as regard duration of first attack, frequency between monosymptomatic to polysymptomatic and complete to partial to no improvement from first attack and percentage of frequency of each of all MRI locations. Conclusion: Pediatric and adult MS are similar as regard presentation ,progression and localization.

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References

  1. Benson, L, Healy B. C., Gorman M. P., Baruch, N. F., Gholipour, T., Musallam, A., &Chitnis, T (2014). Elevated relapse rates in pediatric compared to adult MS persist for at least 6 years. MultSclerRelatDisord 3(2), 186-193
  2. Chabas D, Castillo-Trivino, T., Mowry, E. M., Strober, J. B., Glenn, O. A., &waubant, E. (2008). Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology 71 (14). 1090-1093.
  3. Chong, H., Li, P., & Benjamin, O. (2007). Pediatric multiple sclerosis is similar to adult-onset form in Asia. Neurology Asia, 12, 37-40.
  4. EKMEKCI, O., YUCEYAR, N., & SAGDUYU, A. K. (2012). Clinical features and Course in Pediatric Onset Multiple Sclerosis. Journal of Neurological Sciences, 29(4)
  5. Ferreira, M. L., Machado, M. I., Dantas, M. J., Moreira, A. J., & Souza, A. M. (2008). Pediatric multiple sclerosis: analysis of clinical and epidemiological aspects according to National MS Society Consensus 2007. ArqNeuropsiquiatr, 66(3B), 665-670.
  6. Ghassemi, R., Antel, S. B., Narayanan, S., Francis, S. J., Bar-Or, A., Sadovnick, A. D., . . . Canadian pediatric Demyelinating Disease Study, G. (2008). Lesion distribution in children with clinically isolated syndromes. Ann Neurol, 63 (3), 401-405.
  7. Huppke, B., Ellenberger, D., Rosewich, H., friede, T., Gartner, J., &Huppke, P. (2014). Clinical presentation of pediatric multiple sclerosis before puberty. Eur J Neurol, 21 (3), 441-446.
  8. Inaloo, S., &Haghbin, S. (2013). Multiple sclerosis in children. Iran J child Neurol, 7 (2), 1-10
  9. Renoux, C., Vukusic, S., Mikaeloff, Y., Edan, G., Clanet, M., Dubois, B., . . . Adult Neurology Departments, K. S. G. (2007). Natural
  10. history of multiple sclerosis with childhood onset. N Engl J Med, 356(25), 2603- 2613.
  11. Tullman, M. J. (2013). Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis. Am J Manag Care, 19 (2 Suppl), S15-20.
  12. Waubant, E., &Chabas, D. (2009). Pediatric multiple sclerosis. Curr Treat Options Neurol, 11(3), 203-210
  13. Weiner, H. L. (2008). A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. Neurol, 255 Suppl 1,3-11.

How to Cite This Article

Mohamed Gomaa, Hossam Egila, Abdulhakim Mohammad, Ashraf El-Mitwalli and Mohamed El-Khateeb. (2019); ADULT AND PEDIATRIC MULTIPLE SCLEROSIS: DIFFERENCES AND SIMILARITIES., Int. J. of Adv. Res., 7 (05), 1201-1206, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9152

Corresponding Author

Hossam Egila

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