01Jun 2019

ESTIMATION OF SERUM COPPER , ZINC AND COPPER ZINC RATIO IN UNTREATED PULMONARY TUBERCULOSIS PATIENTS IN COMPARISION TO HEALTHY SUBJECTS.

  • MD (Assistant Professor), MD (Ex.Sr. Professor & HOD Presently working as sr. consultantant Gheesibai Mittal Hospital and research centre), MD (Sr Professor & HOD)Department of BiochemistryJ.L.N. Medical College & Hospital, Ajmer, Rajasthan, 305001 INDIA.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Several independent studies have shown the role of micronutrients like copper and zinc in controlling the severity of pulmonary tuberculosis.Tuberculosis is an important global health problem which is declared as global emergency by WorldHealth Organization (WHO) in 1993. The basic problem is in early diagnosis of the disease and neglecting the role of essential micro nutritrient like copper, Zinc. Aim: Aim of the present study was to Estimation and correlate fasting serum Zinc,Copper, total protein and albumin in newly detected untreated pulmonary tuberculosis patients of age group from 11 years to 45 years of either sex. To compare the serum copper, zinc level, cu/Zn ratio, total protein and albumin in newly detected untreated pulmonary tuberculosis patients with healthy volunters. Materials and method: The study included 50 newly detected sputum smear positive, untreated pulmonary tuberculosis patients and 50 healthy controls. Serum Copper, Zinc, Total Protein and Albumin were estimated in these subject.Present study was conducted in JLN medical college department of Biochemistry. Results and conclusion: The copper level and Cu/Zn ratio was significantly increased in untreated pulmonary tuberculosis patients with p value of <0.0001. The zinc levels decreased with decrease in total protein and albumin levels when compared to normal healthy group with a significant p value of <0.001. Hence the early and effective diagnosis of tuberculosis in the study group was influenced by factors such as increase copper, decrease zinc levels and increased copper zinc ratio.

  1. Mohan G, Kulshreshtha S, Sharma P. Zinc and Copper in Indian patients of tuberculosis. Biological trace elements research, 2006; 111:63-69.
  2. Bodgen J N, Lintz D I, Joselow M M. Effects of Pulmonary Tuberculosis on Blood Concentration of Copper and Zinc. A J Clin Pathol., 1977; 251-256.
  3. Oyama T, Matsuno K, Kawamoto T. fficiency of Serum Copper / Zinc Ratio for differential diagnosis of Patients with and without Lung Cancer. Bilol Trace Elements Res., 1994; 42:115-127.
  4. McMurry D N, Bartow R A, Mintzer C L, Frontera E H. Micronutrient Status and Immune Function in Tuberculosis. Ann Ny Acad Sci., 1995; 38:287-292.
  5. Bell L, Bhat V, George G, A wotedy A A, Gqaza B. Sluggish glucose tolerance in tuberculosis patients. SAMI, 2007; 97:374-377.
  6. Ramakrishnan K, Shenbagarathi R, Kavitha K, et al., Serum Zinc and albu, in Levels in pulmonary tuberculosis patients with an without HW. Jpn J Infect Dis., 2008; 61:202-204.
  7. Muthuraj M, Kamatchiyammal S, Usharani B, Manupriya S, Ayyappan ARN, Divyalakshmi K, Serum Zinc, Calcium and Albumin Leels in pulmonary Tuberculosis patients co-injected with HIV. Global Journal of Biotechnology and Biochemistry, 2010; 5(1):27-35.
  8. Karyadi E, West CE, Schultink W, et al., A double blient placebo-controlled study of vitamin ? A and Zinc supplementation in persons with tuberculosis in Indonesia-effects on clinical response and nutritional status. Am J Clin Nutro., 200;75:720-727.
  9. Xing Z, Gauldie J, Cox Get et al., IL-6 is an anti inflammatory cytokine required for controlling local or systemic acute
 
  1. inflammatory responses. J Clin Invest., 1998; 101: 311-320.
  2. Gabay C and Kushner I. Acute phase protein and other systemic responses to inflammation. N England J Med., 1999; 340:448-454.
  3. Ciftci T U, Cifti, Yis O, Guney Y, Bilgiham A, Ogreten Soy M. Changes in Serum Selenium, Copper, Zinc levels and Cu/Zn Ratio in patients with pulmonary tuberculosis during therapy. Biol Trace Elem Res., 2003; 95:65-71.
  4. Reza B M, Soheila K, Reza M A, et al., Evaluation of Copper, Zinc and Copper/Zinc ratio in the serum of pulmonary tuberculosis children. Pediatric on Call, 2007; 4:1-6.
  5. Parker M M, Humoller F L, Jahler D J. Determination of Copper and Zinc in Biological Material. Clinical Chemistry, 1967; 13(1): 40-48.
  6. Olyboya P O, Erasmus R T. The Significance of Glucose Intolerance in Pulmonary Tuberculosis. Tubercle, 1990; 71:135.
  7. Dececi F, Ilhan N, Plasma Malondialdehyde and serum trace element concentrations in patients with active pulmonary tuberculosis. Biological Trace Element Res., 2003; 95:29-38.
  8. Mohan G, Kulshreshtha S, Dayal R, Singh M, Sharma P, Effect of Therapy on Serum Zinc and Copper in Primary Complex of Children. Biological Trace Element Res., 2007, 118:184-190.
 

[Varsha Chowdhry, Balram Chowdhry and G.G Kaushik. (2019); ESTIMATION OF SERUM COPPER , ZINC AND COPPER ZINC RATIO IN UNTREATED PULMONARY TUBERCULOSIS PATIENTS IN COMPARISION TO HEALTHY SUBJECTS. Int. J. of Adv. Res. 7 (Jun). 70-74] (ISSN 2320-5407). www.journalijar.com

varsha chowdhry

DOI:

Article DOI: 10.21474/IJAR01/9196      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9196

Download Full Paper

Download PDF No. of Downloads: 15 | No. of Views: 72