INVITRO ANALYSIS OF AYURVEDA DECOCTION AND LIPID FORMULATION PREPARED FROM KRIMIGHNA MAHAKASHAYA GANA AGAINST DERMATOPHYTES.

Many classical literatures are mentioned in Ayurveda and Charakasamhita is one among them.CharakaSamhitahas mentioned 50 groups of drugs as Mahakashayagana. KrimighnaMahakashayagana is one among it which contains 10 drugs used against macrobes and microbes. However the dosage form in which this group of drugs has to be used is not clear. The liberty of deciding the suitable dosage form is left to the descretion of the physician. Kwatha(Decoction) is a primary dosage form where the drugs are boiled with prescribed amount of water and reduced to specific amount. In this preparation water soluble active principles present in the drugs are extracted. When the Kwatha is processed with the drugs in KrimighnaMahakashayagana the attributes of the drugs will be transferred in to water media. Taila(oil) are preparations in which oil is boiled with prescribed Kwatha(decoction) and Kalka(paste) of drugs according to the formulae for specific duration of time, fat soluble active principles of herbs will be transformed to oil media, which can be used internally as well as externally as specified . When the Taila(oil) is processed with the drugs in KrimighnaMahakashayagana the attributes of the drugs will be transferred in to oil media. Krimimentioned in Ayurveda can be compared with microorganism and macroorganism. Among microorganisms, study of pathogenic Fungihas received only scant attention in comparison with other Pathogens. With the control of most Bacterial infections in the developed countries, fungal infection has assumed greater importance. Though anti microbial activity of some of the single constituent of above mentioned KrimighnaMahakashayagana(Combination of 10 drugs) has been carried out, study of the whole group has not carried out. So to establish the Krimighna action w.s.r to anti fungal activity of the drugs of this group is taken up. Since the dosage form in which the medicine has to be administered is not clearly mentioned, two dosage forms namely Kwatha(decoction) and Taila(oil) are selected for present study.