ANTIDIABETIC EFFECT OF CONYZA AEGYPTIACA (L.) DRYAND EX. AITON IS IMPROVED BY SWIMMING IN RAT.

  • Laboratory of Effort Physiology, National Institute of Youth, Physical and Sport Education, University of Abomey-Calavi, 01 Po. Box 169 Porto-Novo, Republic of Benin.
  • Laboratory of Pharmacognosy and Essential Oils, Faculty of Sciences and Techniques University of Abomey-Calavi, 01 Po. Box 918 Cotonou, Republic of Benin.
  • Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi, 01 Po. Box 2009 Abomey-Calavi, Benin.
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Conyza aegyptiaca (C. aegyptiaca) is one medicinal plant used for the treatment of diabetes by African populations. We showed previously that C. aegyptiaca is not toxic in rats, prevents hepatic glucose release and has anti-hyperglycemic properties. In addition to medical treatment, clinicians recommend the practice of Sport and Physical Activity (SPA) in diabetics. Objective: To determine C. aegyptiaca extracts anti-diabetic effect alone and with SPA in streptozotocin-induced diabetic rats. Methods: Serum glucose, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) transaminases, total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), Creatinine (Creat.), potassium (K+), chloride (Cl-), sodium (Na+), calcium (Ca2+) and magnesium (Mg2+) were measured using ELITech reagents. Results: C. aegyptiaca extracts decreased significantly glucose level in diabetic rats compared to control. SPA induced a further decrease in blood glucose in the group treated with Eth. Ext. (p=0.045). In diabetic rats without treatment, SPA induced a significant decrease in blood glucose on day 14 (p=0.047) compared to untrained rats. C. aegyptiaca extracts combined with SPA significantly decreased Creat. (p=0.008), ASAT (p=0.0007), ALT (p=0.045), LDL-C (p=0.01), TG (p=0.007), CT (p=0.045) and increased HDL-C (p=0.008), Na+ (p=0.047) level in diabetic rats compared to untrained diabetic. Conclusion: Our results suggest that C. aegyptiaca has greater antidiabetic properties when aqueous extracted, and the practice of SPA improves these properties.

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[Bai Huguette Akakpo, Casimir Dewanou Akpovi, Judith Fifamin Ahounou Aikpe, Mansourou Moudachirou, Joachim Djimon Gbenou and Pierre Houndjovi Dansou. (2019); ANTIDIABETIC EFFECT OF CONYZA AEGYPTIACA (L.) DRYAND EX. AITON IS IMPROVED BY SWIMMING IN RAT. Int. J. of Adv. Res. 7 (Jul). 220-230] (ISSN 2320-5407). www.journalijar.com

Baï Huguette Akakpo
Laboratory of Effort Physiology, National Institute of Youth, Physical and Sport Education, University of Abomey-Calavi, 01 Po. Box 169 Porto-Novo, Republic of Benin.

DOI:

Article DOI: 10.21474/IJAR01/9348      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9348

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