Vol. 7 (07) pp. 980-985 DOI: 10.21474/IJAR01/9454

ASSESSMENT OF THE RELATIONSHIP BETWEEN THE MONITORING RESULTS OF PATIENTS WITH VIRAL HEPATITIS-RELATED HEPATOCELLULAR CARCINOMA AND TYPE 2 DIABETES MELLITUS.

, , and
  • Department of Internal Medicine, ZBEU, Turkey.
  • Department of Internal Medicine, Denizli Government Hospital, Turkey.
  • Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Turkey.
16 Downloads 106 Views
Crossref

Download Full Paper (PDF)

Abstract

Background:Among the etiological factors of hepatocellular carcinoma (HCC), which is the most frequently encountered cause of primary liver cancers, viral hepatitis cases are at the top. The relationship between glucose anomalies and HCC development in especially patients with viral hepatitis C and B infections is still a topic of curiosity. In this study, we aimed to assess the potential relationship between the chronic hepatitis C and B infections (HBV and HCV) in monitoring of HCC patients and type 2 diabetes mellitus (DM) comorbidity. Material and Method:A total of consecutive 51 HCC patients with a mean age of 69.98?11.92 years were enrolled in this study. The Barcelona-Clinic Liver Cancer (BCLC) criteria were used for staging the patients with HCC. HBsAgseroprevalence with the Anti-HCV antibody was studied with the ELISA method. The patients were grouped based on presence of diabetes, and the relationships between disease stages and viral etiological factors were statistically analyzed. Results:In patients with HCC, DM prevalence was 41.2%. 55.6% of Chronic hepatitis C patients and only 33.3% of chronic hepatitis B patients had diagnoses of DM (p=0.107). According to the BCLC stages in the patients, the DM rates at A, B, and C were 40%, 45.5% and 50% respectively (p<0.05). Conclusion:Blood sugar regulation in chronic viral hepatitis patients with DM may contribute to reduction of HCC risk.

Keywords

How to Cite This Article

Yasin Ozturk, Guray Ceylan, Coskun Sokmen and Muammer Bilici. (2019); ASSESSMENT OF THE RELATIONSHIP BETWEEN THE MONITORING RESULTS OF PATIENTS WITH VIRAL HEPATITIS-RELATED HEPATOCELLULAR CARCINOMA AND TYPE 2 DIABETES MELLITUS., International Journal of Advanced Research (IJAR), 7 (07), 980-985, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9454

Corresponding Author

Muammer Bilici
Bulent Ecevit University

Article Analytics

References

  1. McKeating C, Cadden I, McDougall N, Jessop L, Quah S, Lavelle M, et al. Progression from acute to chronic hepatitis B is more common in older adults. The Ulster medical journal. 2018;87(3):177.
  2. Chen SL, Morgan TR. The natural history of hepatitis C virus (HCV) infection. International journal of medical sciences. 2006;3(2):47.
  3. Sanyal AJ, Yoon SK, Lencioni R. The etiology of hepatocellular carcinoma and consequences for treatment. The oncologist. 2010;15(Supplement 4):14-22.
  4. Ghouri YA, Mian I, Rowe JH. Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis. Journal of carcinogenesis. 2017;16.
  5. McCulloch DK, Robertson RP. Risk factors for type 2 diabetes mellitus. UpToDateDisponibleen: URL: http://www uptodate com/contents/risk-factors-for-type-2-diabetes-mellitus [?ltimoacceso: 23 de febrero de 2015]. 2016.
  6. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, et al. Diabetes and cancer: a consensus report. CA: a cancer journal for clinicians. 2010;60(4):207-21.
  7. Singh MK, Das BK, Choudhary S, Gupta D, Patil UK. Diabetes and hepatocellular carcinoma: A pathophysiological link and pharmacological management. Biomedicine & Pharmacotherapy. 2018;106:991-1002.
  8. Hong YS, Chang Y, Ryu S, Cainzos-Achirica M, Kwon M-J, Zhang Y, et al. Hepatitis B and C virus infection and diabetes mellitus: A cohort study. Scientific reports. 2017;7(1):4606.
  9. Villar LM, Geloneze B, Vasques ACJ, Pires MLE, Miguel JC, da Silva EF, et al. Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals. PloS one. 2019;14(2):e0211193.
  10. Huang ZS, Huang TS, Wu TH, Chen MF, Hsu CS, Kao JH. Asymptomatic chronic hepatitis B virus infection does not increase the risk of diabetes mellitus: a ten‐year observation. Journal of gastroenterology and hepatology. 2010;25(8):1420-5.
  11. Spradling P, Simons B, Narayanan M, Xing J, Homan C, Bulkow L, et al. Incidence of diabetes mellitus in a population‐based cohort of persons with chronic hepatitis B virus infection. Journal of viral hepatitis. 2013;20(7):510-3.
  12. Hammerstad SS, Grock SF, Lee HJ, Hasham A, Sundaram N, Tomer Y. Diabetes and hepatitis C: a two-way association. Frontiers in endocrinology. 2015;6:134.
  13. Llovet JM, Fuster J, Bruix J. The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver transplantation. 2004;10(S2):S115-S20.
  14. Chung RT, Ghany MG, Kim AY, Marks KM, Naggie S, Vargas HE, et al. Hepatitis C guidance 2018 update: AASLD-IDSA recommendations for testing, managing, and treating hepatitis C virus infection. Clinical Infectious Diseases. 2018.
  15. Terrault NA, Lok AS, McMahon BJ, Chang KM, Hwang JP, Jonas MM, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-99.
  16. Association AD. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes?2018. Diabetes care. 2018;41(Supplement 1):S13-S27.
  17. Hum J, Jou JH. The link between hepatitis C virus and diabetes mellitus: Improvement in insulin resistance after eradication of hepatitis C virus. Clinical liver disease. 2018;11(3):73.
  18. Giovannucci E. Nutrition, insulin, insulin-like growth factors and cancer. Hormone and Metabolic Research. 2003;35(11/12):694-704.
  19. Takamura T, Sakurai M, Ota T, Ando H, Honda M, Kaneko S. Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. Diabetologia. 2004;47(4):638-47.
  20. Fong DG, Nehra V, Lindor KD, Buchman AL. Metabolic and nutritional considerations in nonalcoholic fatty liver. Hepatology. 2000;32(1):3-10.
  21. Tan Y, Wei S, Zhang W, Yang J, Yang J, Yan L. Type 2 diabetes mellitus increases the risk of hepatocellular carcinoma in subjects with chronic hepatitis B virus infection: a meta-analysis and systematic review. Cancer management and research. 2019;11:705.
  22. Schwartz JM, Carithers R. Epidemiology and etiologic associations of hepatocellular carcinoma. Wolters Kluwer UpToDate website. www. upto-date. com/contents/epidemiology ?; 2013.
  23. Tanaka K, Hirohata T, Koga S, Sugimachi K, Kanematsu T, Ohryohji F, et al. Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population. Cancer research. 1991;51(11):2842-7.
  24. Fung J, Lai C-L, Yuen M-F. Hepatitis B and C virus-related carcinogenesis. Clinical microbiology and infection. 2009;15(11):964-70.
  25. Su Y-W, Liu P-H, Hsu C-Y, Lee Y-H, Hsia C-Y, Ho S-Y, et al. Prognostic impact of diabetes mellitus on hepatocellular carcinoma: Special emphasis from the BCLC perspective. PloS one. 2017;12(3):e0174333.
  26. Komura T, Mizukoshi E, Kita Y, Sakurai M, Takata Y, Arai K, et al. Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. The American journal of gastroenterology. 2007;102(9):1939.
  27. Huo T-I, Wu J-C, Lui W-Y, Lee P-C, Huang Y-H, Chau G-Y, et al. Diabetes mellitus is a recurrence-independent risk factor in patients with hepatitis B virus-related hepatocellular carcinoma undergoing resection. European journal of gastroenterology & hepatology. 2003;15(11):1203-8.
 

Similar Articles

Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.