12Aug 2019

L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS.

  • Department of Clinical Pathology/Hematology, Biomedical Research, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Department of Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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Background: L-arginine is a multifactorial compound, indirectly involved in multiple regulatory mechanisms substrate for nitric acid synthesis. It has been documented that it has a beneficial effect on insulin resistance in Type 2 Diabetes (T2D) and visceral obesity. Experimental and clinical trials have illustrated the undergoing mechanistic pathways either on molecular or biochemical levels. However, the relationship between L-arginine supplementation and insulin receptor expression has not elucidated. Aim: The study aimed to evaluate the influence of L-arginine supplementation on insulin receptor expression, insulin resistance and weight gain in high fat diet fed rats. Subjects& Methods: 48 female albinos with visceral obesity were randomly assigned to either receive a high fat diet for 12 weeks or L- arginine with a dose of 5% in food for the last 8 weeks. Two age groups were enrolled ?adult and old?, Biochemical analysis was performed including: the concentration of insulin receptor expression in visceral fat, plasma insulin receptor and fasting blood glucose, the insulin resistance was evaluated according to the homeostasis model assessment- insulin resistance (HOMA-IR) protocol. Results: The concentration of insulin receptors was significantly higher in L-arginine treated group and associated with significant decrease in HOMA_IR and insulin concentration. In addition, the influence of L-arginine is conversely proportional with age. Conclusion: our results supports the hypotheses that dietary L-arginine supplementation results in increase insulin receptors, which could lead to negative feedback on insulin resistance.

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[Nashwa EL-Khazragy and Dalia A. Saad. (2019); L-ARGININE SUPPLEMENTATION IMPROVES INSULIN RESISTANCE BY INCREASING THE INSULIN RECEPTOR EXPRESSION IN TYPE II DIABETIC RATS. Int. J. of Adv. Res. 7 (Aug). 702-708] (ISSN 2320-5407). www.journalijar.com

Nashwa EL-Khazragy
Department of Clinical Pathology/Hematology, Biomedical Research, Faculty of Medicine, Ain Shams University, Cairo, Egypt

DOI:

Article DOI: 10.21474/IJAR01/9551      
DOI URL: https://dx.doi.org/10.21474/IJAR01/9551

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