Vol. 7 (10) pp. 318-322 DOI: 10.21474/IJAR01/9834

HEPATOPROTECTIVE ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR RATS.

, , , and
  • Associate Professor&HOD, Vaageswaricollege of pharmacy, Karimnagar, Telangana.
  • Central research institute of unani medicine, Telangana- 505001, India.
  • Director of central research institute of unani medicine, Hyderabad, Telangana,India.
  • Assistant professor, St Peters institute of pharmaceutical sciences, telangana.
  • M. Pharm (Pharmacology), Vaageswari College of Pharmacy, Karimnagar, Telangana, India.
32 Downloads 96 Views
Crossref

Download Full Paper (PDF)

Abstract

Aim:Paracetamol (PCM) overdose induces Hepatotoxicity in humans and experimental animals. The present study aims to evaluate Hepatoprotective activity of Schisandra grandiflora against paracetamol induced hepatotoxicity. Method: In this experimental study wistar albino Rats were selected and Hepatotoxicity induced by paracetamol (PCM) p.o, 3g/kg body weight. On 7th day after the administration of plant extract and silymarin (50mg/kg) the plant extract of Schisandra grandiflora was administered orally at doses of 100mg/kg & 200mg/kg body weight daily for 7 days.Several serum makers, Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alkaline phasphatase (ALP), bilirubin total protein was measured to assess the effect of the extract on paracetamol Induced hepatic damage. A comparative histopathological study exhibited almost normal result as compared as control group.

Keywords

Article Analytics

References

  1. Erdogan?Orhan I, Kartal M, Insight in to research on phytochemistry and biological activitiesofPrunusarmeniacaL(apricot),FoodResearchInternational.2011;44(5):1238-43.
  2. Dinesh K, SivakumarV, Selvapriya B, Deepika E, MohamedSadiqA.Evaluationof hepatoactivepolyherbalformulationscontainssomeIndianmedicinalplants.JournalofPharmacognosy and Phytochemistry. 2014; 3(4):1-5.
  3. Dahlin CD, Miwa G, Lu A, Nelson S. N-acetyl-p-benzoquinoeimine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl ACADSci1984; 81(5):1327-31.
  4. Elmhdwi MF, Muftah SM, Tumi SGE, Elslimani. Hepatoprotective effect ofEcballium elaterium fruit juice against paracetamol induced hepatotoxicity in male albino ratInternational current Pharmaceutical J. 2014; 3(5):270-74.
  5. Varsha Raj*, Arun Kumar Mishra, Amrita Mishra, Najam Ali Khan Hepatoprotective effect of Prunusarmeniaca (Apricot) leaf extracts on Paracetamol induced liver damage in Wistar rats
  6. Organisation for Economic Co-operation and Development Guidelines on acute oral toxicity. Revised Document. October 2005.
  7. Pal A, Banerjee B, Banerjee T, Masih M, Pal K. Hepatoprotective activity ofChenopodium album Linn plant against Paracetamol-induced hepatic injury inrats In Journal of Pharmacy and Pharmaceutical Science 2011; 3(3):55-7.
  8. Gupta AK, Misra N. Hepatoprotective activity of aqueous ethanolic extract of Chamomile capitulain paracetamol intoxicated albino rats. Am J PharmacolToxicol, 2006; 1:17-20.
  9. Malloy HT, Evelyn KA. The determination of bilirubin with the photochemical colorimeter. J. Biol. Chem.1937; 119:481-490.
  10. Nithianantham K, Shyamala M, Chen Y, Latha LY, Jothy SL, Sasidharan S. Hepatoprotective potential of Clitoriaternatealeaf extract against paracetamol induced damage in mice. Molecules, 2011; 16:10134-10145.
  11. Reitman S, Frankel S. In vitro determination of transaminase activity in serum. Amer J Clin Pathol.1957; 28:56.
  12. RK Patel, MM Patel, MP Patel, NR Kanzaria, KR Vaghela, NJ Patel. Phcog mag., 2008, 4:118‐
  13. MC Savides, FW Oehne. Journal of Applied Toxicology, 1983, 3:95‐
  14. OECD: Guidelines for the Testing of Chemicals/Section 4: Health Effects Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure. Paris, Organisation for Economic Co-operation and Development Publishing, 2008.
  15. Uti?rrezl, R.M.P. and Slo?s, R.V.: Rec. Nat. Prod., 3(1):46-51 (2009).
  16. Sallie, R., Tredger, J.M. and William, R.: BiopharmDrug Disp., 12: 251-259 (1991)
  17. Thabrew, M. and Joice, P.: Planta Med., 53: 239?241(1987).
  18. Gupta, A.K. and Misra, N.: Am J PharmacolToxicol., 1: 17-20 (2006).
  19. SudheendraHonwad, T ShridharaBairy, Ravi M, B Ravishankar2015 Hepatoprotective activity of SomanathiTamraBhasma in paracetamol induced liver toxicity
  20. Larrey D. Drug induced liver disease. J Hepatol 2003;32:77‐

How to Cite This Article

Challa Pradeep kumar, Penchala Prathap, Munawwar Husain Kazmi, B. Suhasini and Srujana thatipelly. (2019); HEPATOPROTECTIVE ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN WISTAR RATS., Int. J. of Adv. Res., 7 (10), 318-322, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9834

Corresponding Author

Srujana thatipelly
M. Pharm (Pharmacology), Vaageswari College of Pharmacy, Karimnagar, Telangana- 505001, India.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.