COMPARISON OF RED CELL DISTRIBUTION WIDTH (RDW) AND APACHE II SCORE AS PROGNOSTIC MARKER AMONG PATIENTS OF SEPSIS AND SEPTIC SHOCK IN A TERTIARY CARE INSTITUTE, SOUTHERN RAJASTHAN
- Resident, Dept of Medicine, Maharana Bhupal Associate group of hospitals and RNT Medical College, Udaipur, Rajasthan[India]
- Professor , Dept of Medicine, Maharana Bhupal Associate group of hospitals and RNT Medical College, Udaipur, Rajasthan[India]
- Senior Professor, Dept of Medicine, Maharana Bhupal Associate group of hospitals and RNT Medical College, Udaipur, Rajasthan[India]
- Resident, Dept of Medicine, Maharana Bhupal Associate group of hospitals and RNT Medical College, Udaipur, Rajasthan[India]
- Resident, Dept of Preventive and Social Medicine, Maharana Bhupal Associate group of hospitals and RNT Medical College, Udaipur, Rajasthan[India]
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Abstract
Despite advancements, severe Sepsis and septic shock are increasing and contributing significantly to mortality. Acute Physiology and Chronic Health Evaluation (APACHE) II scoring is used as an index of illness severity and for outcome prediction. However, calculating it is cumbersome. Recent studies reported that Red Cell Distribution Width (RDW) is associated with prognosis in Critical Illness and as a part of Complete Blood Count, it is tested in all patients of sepsis. Hence, this study is being done to see correlation between RDW and sepsis.
Materials and methods: A hospital-based prospective observational study done for a year on 50 patients admitted with sepsis and septic shock in the intensive care units of RNT Medical College & MBGH, Udaipur after taking consent. The necessary details were taken in Proforma and data was analyzed in MS excel and the results were interpreted & significance was attributed to P <0.05
Results: Out of 50 patients- 21 were non-survivors, 15(71.43%) were males & most of the patients in the age group of 41-60 years (47.62%) in non-survivors. Amongst survivors, 19 (65.52%) were males & most of the patients in the age group of 61-80 years (37.93%) Mean APACHE II score among non-survivors was 30.43?6.14 and 16.14?6.50 among survivors. Mean RDW among non-survivors was 16.09?2.24 and among survivors was 14.45?1.45.
Conclusion: There was a statistically significant positive correlation between APACHE II & RDW among survivors and non-survivors. In
developing countries like India, RDW levels measured on admission can be used as a prognostic marker in severe sepsis and septic shock.
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How to Cite This Article
Murugesh Manjunatha, Hemant Mahur, D. P. Singh, Darshan R. S, Shaitan Singh Jat and Rajath Rao (2019); COMPARISON OF RED CELL DISTRIBUTION WIDTH (RDW) AND APACHE II SCORE AS PROGNOSTIC MARKER AMONG PATIENTS OF SEPSIS AND SEPTIC SHOCK IN A TERTIARY CARE INSTITUTE, SOUTHERN RAJASTHAN, International Journal of Advanced Research (IJAR), 7 (10), 1160-1165, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/9937
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References
- Martin GS, Mannino DM,Eaton S,Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. New England Journal of Medicine 2003 Apr 17;348(16):1546-54
- Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, et al. Nationwide trends of severe sepsis in the 21st century(2000-2007). Chest 2011 Nov;140(5):1223-31.
- Angus DC, Linde - Zwirble WT, Lidickee J, Clermont G, Carrillo J, Pinsky MR. Epidemiology of severe sepsis in the United States : Analysis of the incidence, outcome and associated costs of the care. Crit Care Med 2001 Jul;29(7):1303-1310.
- Qiao Q, Lu G, Li M, Shen Y, Xu D.Prediction of outcome in critically ill elderly patients using APACHE II and SOFA scores. J Int Med Res. 2012;40(3):1114-21.
- Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29.
- Del Prete M, Castiglia D, Meli M, Perri S, Nicita A, Dalla Torre A, Moraldi A. Prognostic value of C reactive protein in acute pancreatitis Chir Ital. 2001 Jan-Feb;53(1):33-38.
- Evans TC, Jehle D.The red blood cell distribution width. J Emerg Med. 1991;9 Suppl 1:71-74
- Fukuta H, Ohte N, Mukai S, Saeki T, Asada K, Wakami K, Kimura G.Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J. 2009 May;50(3):301-12.
- Felker GM, Allen LA, Pocock SJ, Shaw LK, McMurray JJ, Pfeffer MA, Swedberg K, Wang D, Yusuf S, Michelson EL, Granger CB; CHARM InvestigatorsRed cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol. 2007 Jul 3;50(1):40-7.
- Dabbah S, Hammerman H, Markiewicz W, Aronson D.Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010 Feb 1;105(3):312-7.
- Zorlu A, Bektasoglu G, Guven FM, Dogan OT, Gucuk E, Ege MR, Altay H, Cinar Z, Tandogan I, Yilmaz MB. Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol. 2012 Jan 1;109(1):128-34.
- Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF, Azzam ZS.Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia.Crit Care. 2011 Aug 11;15(4):R194.
- Bazick, Chang D, Karthik Mahadevappa, Fiona K. Gibbons, Kenneth B. Christopher. Red Cell Distribution Width and all cause mortality in critically ill patients .Crit Care Med. 2011 Aug; 39(8): 1913?1921.
- Kim J, Kim K, Lee JH, Jo YH, Rhee JE, Kim TY, Kang KW, Kim YJ, Hwang SS, Jang HY. Red blood cell distribution width as an independent predictor of all-cause mortality in out of hospital cardiac arrest. 2012 Oct;83(10):1248-52.
- Jo YH1, Kim K, Lee JH, Kang C, Kim T, Park HM, Kang KW, Kim J, Rhee JE.Red cell distribution width is a prognostic factor in severe sepsis and septic shock.Am J Emerg Med. 2013 Mar;31(3):545-8.
- Zhongheng Zhang, Xiao Xu, Hongying Ni, and Hongsheng Deng. Red cell distribution width is associated with hospital mortality in unselected critically ill patients. J Thorac Dis. 2013 Dec; 5(6): 730?736.
- Henry E. Wang, Nathan I. Shapiro, Russell Griffin, Monika M. Safford, Suzanne Judd, George Howard.Chronic Medical Conditions and Risk of Sepsis.PLoS One. 2012; 7(10): e48307.
- John M. A. Bohnen, Robert A. Mustard, Susan E. Oxholm, B. Diana Schouten. APACHE II Score and Abdominal Sepsis. Archives of Surgery, 123(2), 225.
- Mahmood NA, Mathew J, Kang B, DeBari VA, Khan MA. Broadening of the red blood cell distribution width is associated with increased severity of illness in patients with sepsis.Int J Crit Illn Inj Sci. 2014 Oct-Dec;4(4):278-82.
- Braun, Eyal & Kheir, Jad & Mashiach, Tania & Naffaa, Mohammad & Azzam, Zaher. (2014). Is elevated Red cell distribution width a prognostic predictor in adult patients with community acquired Pneumonia? BMC infectious diseases. 14. 129. 10.1186/1471-2334-14-129.
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