Synthesis, characterization and antimicrobial studies on [VO(Lom)2L]Cl3 (L=DMF, An, Py, o-Tol and Et3N)

Five coordinated oxovanadium(V) complexes with lomefloxacin and various monodentate have been prepared. The structure of complexes has been investigated using physicochemical, spectral, elemental analysis as well as thermogravimetric analysis. The data indicate that the lomefloxacin reacted as a bidentate ligand through the pyridone group and one oxygen of carboxylic group. The antimicrobial activities of the complexes, ligands, metal salt and some standard drugs have been evaluated against Staphylococcus aureus (S. aureus), Bacillis subtilis (B. subtilis) and Streptococcus pyogenes (S. pyogenes) as gram positive bacteria and Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumonia (K. pneumoniae) as gram negative bacteria. The result shows the significant increase in the antibacterial activity of the ligand on complexation.