Study on Some Pathological aspects of Salmonella enteridis Experimental Infection in Mice

Infections with Salmonella enteridisconsider the main reason of food poisoning in man and infect other animals species and avian. For the study of pathological lesions caused by S. enteridis in mice.A local strain of this microbial agent were obtained from the central public health laboratory. Reidentification for this bacterial strain were done using, biochemical test, API – 20, BiomerieuxVitek instrument and slide agglutination test. The LD50 were 1.4*106 CFU, then this LD50 dose were I/P inoculated in thirty three mice and eleven mice inoculated with phosphate buffer saline (pbs) as a control group. Three mice were sacrificed every three days intervals for 40 days. Among the pathological lesions were micro abscesses and granulomas seen in liver along the experimental periods. Amyloid, lymphoid hyperplasia and different pathological inflammatory lesions were recorded in liver, gall bladder, spleen, pancreas, lungs, intestine, kidneys, heart, brain and meninges, lymph nodes and in periton. Conclusion: S. enteridis experimental infection gave different pathological lesions in the different organs.