13Feb 2020

ISOLATION & EVALUATION OF ANTIFUNGAL ACTIVITY OF THE SEMI SYNTHETIC DERIVATIVES OF LYCOPENE

  • Ideal College of Pharmacy & Research Institute, Bhal Kalyan, (Affilated to Mumbai University).
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

The aim of the study was to evaluate the antifungal activity of lycopene tomato-extracts and their derivative used in fungal infections against the Candida albicans fungus. Lycopene is red carotenoid pigment having scientific values because of its potential biological function. It has a natural source of antioxidant. This project highlights the scientific value and significance of lycopene as therapeutic agent. Now a day?s human fungal infection and fungal resistance is increasing due to increased Tuberculosis, cancer, HIV and various infections. So is makes necessary to discover or modify the new class of antifungal compounds to treat and cure the fungal infections. As we know that plants contains rich source of many bioactive secondary metabolite such as carotenoids, terpenoids, flavonoids, saponins, alkaloids and other constituents were reported to have in vitro antimicrobial properties. Therefore the research on natural products and isolated contents of natural products has been increases in the recent years due to their easy availability and their importance in drug discovery. The use of herbal antimicrobial such as lycopene and lycopene semi synthetic derivatives have been an alternate and effective way of treating candidiasis fungal infections because of the large scale resistance and adverse activities of the commercially available azole group of synthetic antifungal drugs for e.g. ketoconazole, fluconazole, miconazole, itraconazole etc because azoles antifungal are the most frequent class to treat candida infections. Approximately 1.5 million people affected due to various fungal infections globally.[9] Candidiasis is common and serious fungal infection caused by the candida albicans. However; candida normally lives on the skin surface and inside the body like; gut, vagina, mouth and throat without affecting and causing any problem. It can infect the individual cause infection grows out of control or if is enters deep inside the body for e.g. in brain, kidney and blood stream.

  1. Parmar RB, Baria AH, Faldu SD, Tank HM, Design and Evaluation of Poly-herbal Formulation in Semisolid Dosage Form for its Antibacterial Activity, Journal of Pharmacy Research 2009 ; 2:1095-1097.
  2. Lavecchia, R., and Zuorro, A., 2008, Improved lycopene extraction from tomato peels using cell-wall degrading enzymes. European Food Research and Technology. 228(1): 153-158.
  3. Chandra RV Prabhuji ML ,Roopa DA,Ravirajan S, Kishore HC (2008) ? Efficacy of lycopene in the treatment of Gingivitis: a randomised ,placebo-controlled clinical trial. Khachik F, Carvalho L ,Bernstien PS , Muir GI, Zhao DY, Katz NB (2002) \"Tomato and oral diseases?.
  4. Chen J, Jin K, Chen M, Pei W, Kawaguchi K, Greenberg DA, Simon RP. 1997. Early detection of DNA strand breaks in the brain after transient focal ischemia: implications for the role of DNA damage in apoptosis and neuronal cell death. J. Neurochem. 69: 232-245.
  5. Costa V, Moradas-Ferreira P. 2001. Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights in to aging, apoptosis and disease. Mol. Aspects Med. 22: 217-246.
  6. Cozzi R, Ricordy R, Aglitti T, Gatta V, Perticone P, De Salvia R. 1997. Ascorbic acid and beta-carotene as modulators of oxidative damage Carcinogenesis 18: 223-228.
  7. Sohan Sunil Dhanawade1, Aditya Vikas Sakhare2 ?Isolation of Lycopene from Tomato and Study of Its Antimicrobial Activity? (IJSR) ISSN (Online): 2319-7064 Impact Factor (2012): 3.358.
  8. European Commission. 1994. European Parliament and Council Directive 94/36/EC of 30 June 1994 on colours for use in foodstuffs. Official Journal of the European Communities, L 237, 13-29.
  9. Felix Bongomin, ?Global and multi-national prevalence of fungal disease ? estimate precision? Journal of Fungi (MDPI), 3(4): 57, 2017.
  10. WEBMD- Lycopene ? Vitamins & Supplement
  11. Kin-weng Kong, ?Revealing the power of the natural red pigment lycopene- Review? molecules, ISSN- 1420-3049, 15, 959-987, 2010.
  12. Eicher, T.,?The Chemistry of heteocycles: structure, reaction, synthesis, and application (2nd edition) John Wiley & Sons. ISBN 3-527-30720-6.
  13. Sardul singh, ?Antifungal Azole Derivatives and their Pharmacological Potential: Prospects & Retrospects? Bentham Science Publisher, 2210-3155/14, 2014.
  14. Chem Tube 3D ? Electrophilic addition to butadiens.
  15. F. Hatch, P.D. Gardner and R.E. Gilbert, J. Am. Chem. Soc., 1959, 81, 5943- 5946.
  16. Myong?Kyun RoH ? A Simple method for isolation of lycopene from lycopersicon esculentum? Phytochemistry ? Botanical Science 91 (2) : 187-192, 2013.
  17. Lycopene ?Pubchem, US ? National Library of Medicine ? 2016, Retrieved 13 October 2016.
  18. Https:\\\\status.libretexts.Org
  19. Slide player ? 111 Handout #6 Organic Chemistry 1 professor Dr. N. Noureldin winter 2015\\2016 November.
  20. NIH ? U.S. National library of medicine National centre for Biotechnology Information.
  21. Hand book of TLC J. Sherman & B. Fried, Eds., Marcel Dekker, New York, NY, 1991.
  22. TLC 2nd edition E. Stahl, Spronger ? Verlag, New-York, NY, 1969.
  23. TLC reagent & detection methods, Vol. 1a: Physical & Chemical detection methods: Fundamentals reagent \\H.H. Jork, W. funk, W. fischer & H. wimmer, VHC, Weinhein, Germany, 1990.
  24. TLC: Techniques of chemistry, Vol. 14, 2nd edition, J. G. kirchner & E.S. Perry, Eds., John Wiley & sons, 1978.
  25. com, ?Alkenes and sulphuric acid? Jim Clark 2003 (modified August 2015).
  26. Jim Clark, CHEMISTRY LIBRETEXTS, ?Reaction of alkenes with sulfuric acid? June 6, 2019.
  27. Kumar A, ?Efficacy of lycopene in the management of oral sub mucous fibrosis? Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007.
  28. Agarwal S, ?Tomato lycopene and its role in human health and chronic disease? CM AJ 2000.
  29. Singh M, Keluskar V. ?Efficacy of oral lycopene in the treatment of oral leukoplakia.
  30. Gupta PC, Hebert JR, ?Dietary factors in oral leukoplakia and sub mucous fibrosis in a population based case control study in Gujarat? India, Oral Dis 1998.
  31. Gupta AK, Nicol K, ?The use of sulfur in dermatology? J Drugs Dermatol 2004 Jul-Aug; 3(4): 427-31.
  32. Paola D?az Dellavalle1 , Andrea Cabrera1 , Diego Alem1 , Patricia Larra?aga1 , Fernando Ferreira2, ?Antifungal activity of medicinal plant extracts against phytopathogenic fungus Alternaria SPP.? Chilean Journal Of Agricultural Research 71(2) APRIL-JUNE 2011.
  33. Mahlo, Salome Mamokone et al. ?Antioxidant and antifungal activity of selected medicinal plant extracts against phytopathogenic fungi??African Journal Of Traditional, Complementary, And Alternative Medicines : AJTCAM 13,4 216-222. 3 Jul. 2016, doi:10.21010/ajtcam.v13i4.28.
  34. ?Collins & Lyne?s? ?Microbiological Methods?, 8th
  35. Ambikapathy, V., Gomathi, S., and Panneerselvam, A., ?Effect of antifungal activity of some medicinal plants against Pythium debaryanum (Hesse)?, Asian Journal of Plant Science and Research, 2011, 1 (3): 131-134.
  36. , D. A. M., Cardenas O., J. Pacheco, ?Antifungal activity of chloroform & acetone extract of Solanus dolichosepalum against fusarium oxysporum? International Journal of Pharmacy & Pharmaceutical Science, Vol. 8, no. 8, June 2016, PP. 373-4.
  37. Zaman Ashraf, ?In ? Vitro antibacterial & antifungal activity of methanol, chloroform & aqueous extracts of origanum vulgare & their comparative analysis? International Journal of Organic Chemistry, 2011, 1, 257-261, 2011.
  38. Smania, A., Monache, ?Antibacterial activity of steroidal compounds isolated from ganoderma applanatum fruit body? Int. J. Med. Mushrooms, 1, 325-330, 1999.
  39. Vanden Berghe, Vlietinck, ?Screening methods for antibacterial and antiviral agent from higher plants. In: Dey, P.M. Harbone D., Methods in Plants Biochemistry, Academic Press, London, p. 47-69, 1991.
  40. Clinton, S.K. ?Lycopene: chemistry, biology, and implications for human health and disease?, Nutr. 56, 35?51, Rev. 1998.
  41. During, A.; Harrison E.H. ?An in vitro model to study the intestinal absorption of carotenoids? Food Res. 38, 1001?1008, Int. 2005.
  42. Krinsky , N.I.; Johnson, E.J. ?Carotenoid actions and their relation to health and disease? Mol. Aspects Med. 26, 459?516, 2005.
  43. During, A.; Harrison, E.H. ?Intestinal absorption and metabolism of carotenoids Insights from cell culture? Arch. Biochem. Biophys., 430, 77?88, 2004.
  44. Rold?n-Guti?rrez, J.M.; Dolores Luque de Castro, M. ?Lycopene: The need for better methods for characterization and determination? Trends Anal. Chem., 26, 163?170, 2007.
  45. Goralczyk, R.; Siler, U. ?The Role of Lycopene in Human Health. In Phytochemicals in Health and Disease? Bao, Y., Fenwick, R., Eds.; Marcel Dekker Inc: New York, NY, USA, pp. 285?309, 2004.
  46. Zaripheh, S.; Boileau, T.W.-M.; Lila, M.A.; Erdman, J.W. Jr. ?Lycopene and [14C]-labeled polar products are differentially distributed in tissues of F344 rats prefed lycopene? J. Nutr. 133, 4189?4195, 2003.

[Gayatri Gautam Varma, Pragya Seth and Shubhangi Kshirsagar (2020); ISOLATION & EVALUATION OF ANTIFUNGAL ACTIVITY OF THE SEMI SYNTHETIC DERIVATIVES OF LYCOPENE Int. J. of Adv. Res. 8 (Feb). 454-464] (ISSN 2320-5407). www.journalijar.com

Gayatri Gautam Varma
Ideal College of Pharmacy & Research Institute, Mumbai University

DOI:

Article DOI: 10.21474/IJAR01/10481      
DOI URL: https://dx.doi.org/10.21474/IJAR01/10481

Download Full Paper

Download PDF No. of Downloads: 74 | No. of Views: 245