Bacillary dysenteriae : (1) Study on experimental pathology of Shigella dysenteriae type 1 in white mice following intraperitoneal infection.

Shigellosis is a highly infectious disease affecting man and the different animal species. For the importance of this disease, this study aimed at to describe the pathological lesions associated with Shigella dysenteriae type1 following experimental infection. For this reason a local strain of Shigella dysenteriae type1 were obtained from public health laboratory. The strain were reidentified using biochemical tests, API-20 test, slide agglutination test and Sereny test in Guinea pigs (induce a Keratoconjuctivitis).The LD50 for this strain was 8×103 CFU in 0.25ml of bacterial suspension were injected 1/P in 45 mice 3 mice sacrificed at 2 days intervals, then different pathological lesions were recorded including a microabscesses in liver, spleen which transform into granulomatous lesions later on. In addition the neutrophils infiltration, mononuclear cells infiltration were seen in the lungs, kidney, brain, periton, heart, intestine together with lymphoid hyperplasia in the lymph node and lymphoid tissue of spleen, peyer’s patches of intestine and peribronchial lymphoid tissue of the lungs.