SPECULATION OF METAL FOR SUITABLE LUTEOLIN – METAL NANOCOMPOSITE FORMULATION THROUGH IN SILICO APPROACH

Nanocomposite formulation has an impact on therapeutics and medical research as we are moving forward in these fields. During the formation of nanocomposite, the most important part is the mode of interaction between drug and nanoparticle. Hence the study about this interaction is necessary for understanding their binding nature. In our present study we selected luteolin as drug molecule because of its remarkable application in combating several diseases. To form nanocomposite, we choose metals which are widely used for nanoparticles synthesis such as gold, silver, copper, iron, zinc, nickel, palladium, platinum, ruthenium, rhodium, cadmium and antimony. Here we used Avogadro software for the formation of model structures and energy minimization of these nanocomposites. From the results, cadmium was found to be most suitable metal to form nanocomposite in association with luteolin having lowest energy level and antimony possesses highest energy level amongst all metals under consideration.