THE PROTECTIVE ROLE OF GARLIC EXTRACT ON WEIGHT OF UTERUS INDUCED BY LEAD ON MICE UTERUS

(i) OBJECTIVE: The study was conducted to evaluate the protective role of garlic extract on the weight of uterus exposed to lead acetate in an animal model. (ii) STUDY DESIGN: Laboratory based Randomized Control Trial (iii) PLACE AND DURATION OF STUDY: Department of Anatomy, Army Medical College in collaboration with National Institute of health from April—June 2013 (iv) MATERIAL AND METHODS: Thirty female BALBc mice were selected. 10 animals were placed in each group. Group A being the control was given normal diet. Group B was given lead acetate at a dose of 30mg/kg/day. Group C was given lead acetate 30mg/kg/day and garlic extract 500mg/kg/day through oral gavage tube for 60 days. Animals were sacrificed and dissected at the end of 60 days. Uterus was removed and weight of uterus was measured using a precision balance. (v) RESULTS: There was decrease in weight of uterus in group B when compared to Group A. But the results were statistically insignificant when group A was compared to group B, and when group B and C were compared. (vi) CONCLUSION: The weight was affected in lead acetate treated group which improved when treated with garlic extract.