MODULATION OF THENRF2 BINDING REGIONS THROUGH SYNTHETIC INHIBITORS

Importance: NFE2 related factor 2 (NRF2) is considered as a master molecule in transcription factors cascade, whereas the activation or suppression of the NRF2 leads to control of the physiological redox stress balance. Recent Views: NRF2 has taken the attention of scientists and researchers when the abnormal structure and expression of the NRF2 appears in many pathological conditions; the majority of NRF2 abnormality is associated with cancer. Here, in the current review, we suggested using synthetic inhibitors to deregulate NRF2 in cancer because many studies have established that the NRF2 may have a role in chemotherapeutics resistance in some way. Critical concept: the NRF2 could be considered as a key to access into the chemotherapeutic resistance world this accessing it may occur through Controlling of other molecules that act on suppression, binding, and activation of NRF2 itself. Future prospect: NRF2 inhibitors are considering as an interesting and highly strong target candidate for cancer therapy strategy.