CHANGES IN THE EXPRESSION OF NOTCH AND HIF-1Α SIGNALING MOLECULES IN PROSTATE CANCER PROGRESSION
- Department of Urology, Zigong Fourth Peoples Hospital, Sichuan, China.
- Department of Reproductive Medicine, Zigong Maternity and Child Healthcare Hospital, Sichuan, China.
- Department of Science and Education, Zigong Fourth Peoples Hospital, Sichuan, China.
- Department of Urology, The Eighth Affiliated Hospital of Sun Yet-Sen University, Guangdong, China.
- Department of Urology, Kaiping Central Hospital, Guangdong, China.
Abstract
Objective: To explore the expression and clinical significance of Notch and HIF-1α signaling molecules in the progression of prostate cancer.
Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression level of Notch1, HIF-1α and Hes1 mRNA by qRT-PCR, in which the protein expression was measured by western blotting and immunohistochemistry staining, respectively. Correlation between molecules above and clinical pathological parameters were further analyzed.
Results: Both Notch signaling and HIF-1α signaling molecules were overexpressed in prostate cancer on the protein level as well as mRNA level when compared to the para-caner tissues (P<0.05). The expression of these molecules were positive related to local lymphatic metastasis (P<0.05). However, this difference was not significant both in tumor volume and patient’s age.
Conclusion: Both Notch signaling and HIF-1α signaling pathway related molecules were overexpressed in prostate cancer, which might play an important role in the progression of prostate cancer.
Keywords
Article Analytics
How to Cite This Article
Wei Chen, Li-Na He, Cheng-Wu He, Xiang Zeng, Guang-Qing Fu, Ming-Qiang Su, Xin-Yang Fu, Jian-Hui Liu and Yong Liang (2020); CHANGES IN THE EXPRESSION OF NOTCH AND HIF-1Α SIGNALING MOLECULES IN PROSTATE CANCER PROGRESSION, Int. J. of Adv. Res., 8 (07), 1636-1641, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/11433
Corresponding Author
This work is licensed under a Creative Commons Attribution 4.0 International License.