EXPERIMENTAL STUDIES ON HARAGOURIRASA W.S.R TO MRITANI LOHANI RASI BHAVANTI

Ayurveda, one of the ancient systems of medicine, holds a vast domain of traditional knowledge within himself. It is considered as the science of life and has been practiced in India since times immemorial. A very systematic and elaborate step-wise procedure known as ‘Bhasmikarana converts the metal from its zero valent state to a form with higher oxidation state, which is crucial from the point of view that during this process the toxic nature of the metal and its oxide is fully destroyed while rendering the metal oxide with high medicinal value. The mentioned Verse is in the text like Rasendra mangal, Rasarnava, Ras Ratna Samuchchaya, Ras Ratnakar, The verse signifies that the absorption &assimilation of different types of Bhasma of minerals / metals / sub metals & Sindoora kalpana for internal administration in human body. Reduction in the particle size is the motto of using in the form of Bhasma or Nano medicine. The finer the particle size of bhasma allows better rate of assimilation and absorption. This is a critical attempt to understand and apply the basis of Ayurvedic concept of Bhasma and the concept of Pharmacokinetics. Pharmacokinetics supports the studies of preclinical toxicology in animals (toxicokinetics) because the drug levels in plasma or tissues are often more predictive than the dose to extrapolate the toxicity data to man.