Potentiometric and Spectrophotometric Studies of (E)-2-(mercapto-phenylamino-methylene)-3-oxo-N-p-tolyl-butanamide (MPMPB) with Some Metal Ions.

Complexes of V(V), Co(II), Ni(II), Cu(II), Pd(II) and Cd(II) with (MPMPB) have been investigated in solution using Potentiometric and spectrophotometric methods. The composition of the complexes was determined to be 1:1 and/or 1:2 (M: L), the optimum conditions favouring the formation of the coloured complexes were studied extensively; protonation constants and their stability constants of the complexes were calculated. Adherence to Beer\'s law was observed for the µgmL-1 concentration range. Moreover, the solid complexes have been characterized by elemental analyses, electronic spectra, thermal method (TGA and DTA), IR and X-ray powder diffraction. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria S. marcescens (-ve), P. eruginosa (-ve), E. coli (-ve), S. aurous (+ve), B. cereus (+ve) and M. luteus and also the fungi C. albicans (-ve), G. Candidum (-ve), A. flavus (+ve), F.oxysporium (-ve), S. brevicaulis (+ve) and T.rubrum and results have been compared with the standard drug,