Preparation, characterization and median lethal dose (LD50) of carboxymethyl chitosan as target Drug Delivery
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Carboxymethyl chitosan (CMCS) is promising biopolymer for the development of drug delivery systems. CMCS is amphiprotic ether, exhibiting enhanced aqueous solubility, excellent biocompatibility, biodegradability, and biological properties. (CMCS) was synthesized by the reaction of chitosan with monochloroacetic acid (MCAA) in the presence of sodium hydroxide NaOH). CMCS was characterized by FTIR, nitrogen, carboxylic content and degree of substitution (DS). The optimum condition for preparing CMCS has wide range of solubility are 2.5 M MCAA in the Presence of 50% NaOH within 3 hrs. at 60oC. CMCS can load hydrophobic drugs and displays strong bioactivity which highlight its suitability and extensive usage for preparing different drug delivery formulations respectively. The median lethal dose (LD50) for CMCS was determined to achieve its ability to be used as poly load for different drugs. In vivo experiments shows that LD 50 for CMCS showed the safety of the use of this compound in drug delivery systems.
[H. M. Ibrahim, E.M.R. El- Zairy and R. M. Mosaad (2015); Preparation, characterization and median lethal dose (LD50) of carboxymethyl chitosan as target Drug Delivery Int. J. of Adv. Res. 3 (Jan). 0] (ISSN 2320-5407). www.journalijar.com
